active site


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active site:

see enzymeenzyme,
biological catalyst. The term enzyme comes from zymosis, the Greek word for fermentation, a process accomplished by yeast cells and long known to the brewing industry, which occupied the attention of many 19th-century chemists.
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active site

[′ak·tiv ′sīt]
(chemistry)
The effective site at which a given heterogeneous catalytic reaction can take place. Also known as active center.
(cell and molecular biology)
The region of an enzyme molecule at which binding with the substrate occurs. Also known as binding site; catalytic site.
References in periodicals archive ?
In addition, the students will become familiar with [alpha]-amylase enzymes that are a staple in undergraduate biochemistry classes due to the conservation of their active site pocket among species.
The activation involved the movement of the lid helixes which resulted in opening of the lid and providing space for the substrate to interact with the active site.
Then the active site and various conserved motifs of the enzyme were determined by sequence alignment with the lysosomal lipase of Homo sapiens (Accession # CAA83495.
a) The bivalent include bivalirudin and lepirudin; bind both to the active site and Exosite 1 (E1) of thrombin.
Abraham Shanzer of the Organic Chemistry Department, they created an artificial version of the metal zinc-histidine complex at the heart of the MMP9 active site.
Chirality in biological nanospaces; reactions in active sites.
However, the molecular weight distributions (MWDs) of the resulting polymers are not controlled well because of the presence of multiple active sites and the heterogeneity of the catalyst system [1-10].
For example, the invention provides a method for identifying a thermostable polymerase having altered fidelity by mutating at least one amino acid residue in an active site O-helix of a thermostable polymerase.
Wedge the paper into a prominent crevice on the surface of the protein model and explain that it represents the active site for what is now an enzyme model (see Figure 2).
Oseltamivir resistance caused by a single amino acid substitution from histidine (H) to tyrosine (Y) at position 274 of the neuraminidase active site has been reported in persons infected both experimentally and naturally with influenza A virus subtype H5N1 (1,2).
Long misperceived in the West as a Conceptualist, Ilya Kabakov is, rather, an imagist and a fantasist who constructs situations in which the work's most active site is the viewer's imagination.
One area of particular interest would be repair of DNA sites damaged by radiation--the scientist would now be able to create a model enzyme active site and include a small piece of DNA to be cleaved.

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