The direct inhibition of aromatase activity by Roundup was verified in human and equine microsomes, two mammalian aromatase models that we have precisely characterized, in order to understand the active site
configuration of this membrane-bound cytochrome P450 (Auvray et al.
Here, the dominant factor is the increase in the reaction rate due to the cumulative effect of active site
addition throughout all fragmentation steps.
Based on this detailed structural information we can now design new synthetic chemicals which bind even more tightly to the endonuclease active site
and thus will potentially be more potent inhibitors of influenza virus replication," the Daily Mail quoted Dr Cusack as saying.
Two divalent mete ions in the active site
of a new crystal form of human apurinic/apyrimidinic endonuclease Ape1: implications for the catalytic mechanism J Mol Biol 307:1023-1934.
The molecules bind to a small number of very specific sites, including the active site
Some apparently pry apart a base pair, then rotate one of the freed nucleotides, bringing its base out of the confines of the double helix and into the enzyme's active site
, a pocket within the protein's structure.
Of the seven, one of the most significant concerns Angeion's process to identify the active site
of cells which are responsible for conflicting electrical charges causing rapid heartbeats.
Moreover, the amino acids lining the active site
form a shape that makes it difficult for proteins to bind there.
An unusual feature of urease is its dependence on nickel to grab onto and break up urea in the enzyme's active site
, Karplus points out.
The aspirin lodges itself in the cyclooxygenase active site
channel (pink), which lies within that skeleton.
The elucidation of the three-dimensional structure of the HDAC-8 isoform with inhibitors bound at the active site
was instrumental in the discovery and design of selective and potent HDAC inhibitors with good pharmaceutical properties.
The researchers suggest that this misfit is located in the so-called active site
of the enzyme.