active site


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active site:

see enzymeenzyme,
biological catalyst. The term enzyme comes from zymosis, the Greek word for fermentation, a process accomplished by yeast cells and long known to the brewing industry, which occupied the attention of many 19th-century chemists.
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active site

[′ak·tiv ′sīt]
(chemistry)
The effective site at which a given heterogeneous catalytic reaction can take place. Also known as active center.
(cell and molecular biology)
The region of an enzyme molecule at which binding with the substrate occurs. Also known as binding site; catalytic site.
References in periodicals archive ?
The direct inhibition of aromatase activity by Roundup was verified in human and equine microsomes, two mammalian aromatase models that we have precisely characterized, in order to understand the active site configuration of this membrane-bound cytochrome P450 (Auvray et al.
Here, the dominant factor is the increase in the reaction rate due to the cumulative effect of active site addition throughout all fragmentation steps.
Based on this detailed structural information we can now design new synthetic chemicals which bind even more tightly to the endonuclease active site and thus will potentially be more potent inhibitors of influenza virus replication," the Daily Mail quoted Dr Cusack as saying.
Two divalent mete ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease Ape1: implications for the catalytic mechanism J Mol Biol 307:1023-1934.
The molecules bind to a small number of very specific sites, including the active site.
Some apparently pry apart a base pair, then rotate one of the freed nucleotides, bringing its base out of the confines of the double helix and into the enzyme's active site, a pocket within the protein's structure.
Of the seven, one of the most significant concerns Angeion's process to identify the active site of cells which are responsible for conflicting electrical charges causing rapid heartbeats.
Moreover, the amino acids lining the active site form a shape that makes it difficult for proteins to bind there.
An unusual feature of urease is its dependence on nickel to grab onto and break up urea in the enzyme's active site, Karplus points out.
The aspirin lodges itself in the cyclooxygenase active site channel (pink), which lies within that skeleton.
The elucidation of the three-dimensional structure of the HDAC-8 isoform with inhibitors bound at the active site was instrumental in the discovery and design of selective and potent HDAC inhibitors with good pharmaceutical properties.
The researchers suggest that this misfit is located in the so-called active site of the enzyme.

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