DOT1L is a HMT that leads to the development of acute leukemia
associated with rearrangements of the MLL gene on chromosome 11.
JL-1 is expressed on tumor cells of T, B, and myeloid lineages in more than 80% of acute leukemia
patients, but not on mature peripheral blood cells or other normal tissues.
Cases with <20% blast cells may still be diagnosed as acute leukemia
if they present with certain recurrent cytogenetic abnormalities, as in AML M4 with inv (16) or t (16;16) (p13;q22) and AML M2 with t (8), (21)
Patients with relapsed or refractory acute leukemia
who have prior treatment with approved chemotherapeutics generally have a poor prognosis at this point in the disease and are in need of new agents.
In a separate cohort of 36 patients with acute leukemia
, elimination of postgraft G-CSF did not adversely affect engraftment nor increase the incidence of graft-versus-host disease.
These results suggest an NK precursor acute leukemia
About mixed lineage leukemia (MLL-r) MLL-r is an aggressive subtype of two of the most common forms of acute leukemia
, acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), caused by a chromosomal translocation involving the MLL gene.
Fortunately, transformation of PV to acute leukemia
is uncommon, and although very rare, transformation to AML-M7 is also a consideration in patients who experience rapid clinical deterioration.
Interviewed Experts Cite High Unmet Need for Better-Tolerated Treatments Directed Toward Elderly Patients with Acute Leukemia
, According to Findings from Decision Resources
Approximately 300,000 new cases of leukemia are diagnosed worldwide each year, and there are about 36,000 new cases of acute leukemia
in the seven major pharmaceutical markets*.
One of the Company's lead drug candidates, L-Annamycin, is being developed as a treatment for forms of relapsed acute leukemia
, a currently incurable blood cancer.
and their colleagues at Johns Hopkins University School of Medicine in the May 15, 2000 issue of the journal, "Blood," provides a model for how to use GVAX(R) cancer vaccine following bone marrow transplantation in humans with hematologic cancers such as acute leukemia
and multiple myeloma.