Transcription regulation of peroxisomal fatty acyl CoA
oxidase and enoy-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators.
Whatever the precise mechanism by which PPs induce rodent liver cancer, rodent liver peroxisome proliferation, induction of the peroxisomal gene acyl CoA
oxidase (ACO) (23), hypertrophy (24), and carcinogenicity (25) are all mediated through activation of the peroxisome proliferator-activated receptor (PPAR[alpha]).
21)--the carnitine palmitoyl transferase (CPT), which is located at the inner side of the outer mitochondrial membrane, transesterifies the long-chain fatty acid and transports the acyl CoA
across the inner mitochondrial membrane, where CPT II is located, to break the acyl bond releasing the fatty acid, and recycling CoASH (2, 6-8).
Many disorders and syndromes were eliminated as the focus turned to something called short-chain acyl CoA
dehydrogenase deficiency, a fatty acid oxidation disorder within the larger category of mitochondrial disorders.