Stimulation of these receptors inhibits adenylcyclase via a G protein, thereby reducing intracellular cyclic-adenosinemono-phosphate (c-AMP) concentrations (17).
2]) and thrombin, but in lower concentrations than those required for inhibition of adenylcyclase or stimulation of PLC.
Prostacyclin, released by intact endothelium, inhibits further platelet activation by stimulating adenylcyclase, thereby increasing platelet c-AMP levels.
Even if all the COX-1 is inactivated, platelets will still respond to higher concentrations of other agonists through separate pathways involving adenylcyclase or PLC (Figure 1).
Additionally during the quarter, the Company announced collaborations with Collateral Therapeutics for adeno-associated virus (AAV) delivery of the adenylcyclase
(AC) gene, Copernicus Gene Systems for the development of non- viral gene therapy vectors, and The National Heart, Lung and Blood Institute/National Institutes of Health for investigations of AAV-based gene transfer to liver and other tissues.