adrenochrome


Also found in: Dictionary, Medical, Wikipedia.
Related to adrenochrome: DMT

adrenochrome

[ə′dren·ə‚krōm]
(biochemistry)
C9H9O3N A brick-red oxidation product of epinephrine which can convert hemoglobin into methemoglobin.
References in periodicals archive ?
If we could decrease the formation of adrenochrome, we would have a treatment for schizophrenia.
And to decrease the oxidation of adrenalin to adrenochrome, we thought that large doses of ascorbic acid, the most effective water soluble antioxidant, would be helpful.
In the early 1950s it was shown that adrenochrome - something like a hybrid of adrenaline and mescaline - could produce symptoms identical with those of schizophrenia.
The American and British Freud-dominated psychiatric establishments angrily denied that adrenochrome and taraxein existed.
However, because oxidation of dobutamine to adrenochrome is rapid (complete within 5 min) under the Boehringer Mannheim reagent conditions, it is clear that reaction with 4-aminophenazone is not required for dobutamine to interfere in peroxidase-based tests.
Dobutamine oxidation under the Boehringer Mannheim reagent conditions was rapid, with complete oxidation to adrenochrome occurring in <5 min.
Hoffer hypothesized that ascorbic acid's antioxidant activity also prevented the conversion of adrenaline to adrenochrome.
Orthomolecular psychiatrist Abram Hoffer identified adrenochrome as a possible factor in schizophrenia when he developed paranoia after ingesting the substance.
What Really Causes Schizophrenia is an expansive look at the biochemistry, research, and history of schizophrenia and the adrenochrome hypothesis.
Osmond and I were invited to one of their meetings in 1952 held in the Canada Room (I thought that was very kind) of the Waldorf Astoria Hotel, where we for the first time reported our new hypothesis about adrenochrome and schizophrenia.
Osmond, I developed the first comprehensive hypothesis of schizophrenia with our adrenochrome hypothesis; this led to megavitamin treatment and, later, to orthomolecular treatment in association with Linus Pauling.