X-linked adrenoleukodystrophy

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X-linked adrenoleukodystrophy

[¦eks ‚liŋkt ə‚drē·nō‚lü·kə′dis·trə·fē]
(medicine)
An inherited peroxisomal disorder in which a defective peroxisomal membrane protein results in impaired ?-oxidation of very long chain fatty acids, which subsequently accumulate in the adrenal glands, nervous system, and testes and disrupt normal activity.
References in periodicals archive ?
Adrenoleukodystrophy presenting as addison'sdisease in children and adults.
It also reviews key players involved in the therapeutic development for Adrenoleukodystrophy (Adrenomyeloneuropathy/ Schilder-Addison Complex).
The exact impact of inclusion of X-linked adrenoleukodystrophy on the uniform newborn screening panel cannot be completely predicted, but based on the information that we already have, we can estimate it will have a significant impact on the acute and sometimes catastrophic effects of adrenal insufficiency and will reduce the numbers of boys with ALD who are ineligible for the life- saving therapy of bone marrow transplantation because they are identified at a time when the brain disease is too advanced.
Little Marc Elliott, who is battling the deadly disease Adrenoleukodystrophy has also been left with "tunnel vision" after losing some of his eyesight following his long-awaited bonemarrow transplant.
Washington, Nov 6 (ANI): Scientists are reporting a new breakthrough in the ongoing battle against a fatal brain disease called adrenoleukodystrophy using gene therapy.
Alfie is the youngest person in the country to inherit a genetic disorder called adrenoleukodystrophy (ALD), which affects only 1 in 40,000 people.
Navarro had "suffered from adrenoleukodystrophy, which causes damage to the nervous system and muscular system.
Lorenzo was six when it was discovered had adrenoleukodystrophy caused by a genetic mutation that breaks down the nervous system.
Scott and Nicola Smith's children ( Connor, eight, Callum, six, and five-year-old Jack ( all suffer from Adrenoleukodystrophy, or ALD.
The film tells the story of a Lorenzo Odone, a young boy affected by the degenerative disease Adrenoleukodystrophy, known as ALD.