Recent reports of adventitious virus contamination of products and production environments have accentuated the necessity of a holistic approach to virus safety.
Recent reports of contamination of bulk harvests, adventitious virus contamination of manufacturing environments and even a marketed vaccine product have shone the spotlight on the vulnerability of all pharmaceutical/biopharmaceutical operations.
little/no change in cell viability and other parameters, in which case the production may go to completion, and will likely only be detected during adventitious virus testing of the bulk harvest.
Retrospectively, it was determined that the initial BPV inoculum in 1996 only, was contaminated with an adventitious virus and the RSV titer was practically non-existent.
b)Retrospectively, it was determined that the Parvovirus incolum in 1996 was contaminated with an adventitious virus.