aequorin


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aequorin

[′ē·kwə‚rin]
(biochemistry)
A bioluminescent protein that is produced by jellyfish of the genus Aequorea and emits light in the presence of calcium or strontium.
References in periodicals archive ?
The new aequorin option enables cell suspension assays, thereby minimizing cell preparation time and reducing assay costs.
With the addition of the aequorin option for FLIPR Tetra, we can offer FLIPR(R) users the added benefits of reduced assay costs and fewer technical requirements associated with running aequorin applications," said Andy Boorn, President of MDS Analytical Technologies.
A part of aequorin called coelenterazine reacts with oxygen to produce coelenteramide and carbon dioxide, while emitting light.
Aequorin assays are a sensitive and flexible cell-based assay technology used to detect GPCR activation with several advantages over conventional fluorescence based dyes, including fewer false positives, much simpler protocol and significantly increased assay windows.
The aequorin technology will be used as part of nationwide GPCR screening campaigns and drug discovery programs in Korea.
Once the ability of aequorin to protect brain cells from death was proven and the research results were published and presented at national scientific conferences, Underwood and his team at Quincy Biosciences concentrated their efforts on the manufacturing and launch of Prevagen as a dietary supplement.
Aequorin was first isolated from simple marine jellyfish in the 1960s and then identified as a member of a family of proteins that binds to calcium and influences cell functions throughout the body.
Studies conducted by Quincy Bioscience in conjunction with scientists at the University of Wisconsin-Milwaukee have shown that the jellyfish protein aequorin results in a significant reduction of brain cell death in their animal studies.
Aequorin Technology Would Strengthen Leadership Position in GPCR Screening