afibrinogenemia


Also found in: Dictionary, Thesaurus, Medical.
Related to afibrinogenemia: hypofibrinogenemia, dysfibrinogenemia

afibrinogenemia

[‚ā·fī¦brin·ə·jə′nē·mē·ə]
(medicine)
Complete absence of fibrinogen in the blood.
Mentioned in ?
References in periodicals archive ?
The patient who presented to the Pediatric Hematology Outpatient clinic because of unstoppable gingival bleeding for the first time in 2006 was diagnosed with congenital afibrinogenemia with findings including a prothrombin time (>120 s) and an activated partial thromboplastin time (>120 s) which were too long to be measured and a fibrinogen level which was too low to be measured.
Splenic rupture is observed more commonly in congenital afibrinogenemia compared to the other congenital bleeding disorders.
64) Afibrinogenemia, a rare deficiency of fibrinogen, can present with similar initial platelet aggregation results, but the aggregation defect in afibrinogenemia is restored with addition of fibrinogen to the specimen.
Patients with afibrinogenemia or Glanzmann thrombasthenia (abnormalities of the GP Iib-IIIa receptor) lack both primary and secondary responses to various platelet agonists (27).
Differential Diagnosis of Menorrhagia in an Adolescent Anatomic abnormality Genital neoplasm (sarcoma botryoides) Genital trauma or laceration Severe vaginitis (especially streptococcal) Foreign body Prolapsed urethra Bleeding abnormality Platelets Platelet dysfunction Thrombocytopenia Clotting disorder Hemophilia A von Willebrand's disease Afibrinogenemia Hypoprothrombinemia Dysfibrinogenemia Induced disorder Ingestion of antiplatelet drugs (aspirin) Hormonal abnormality Anovulatory bleeding Pregnancy complication Threatened abortion
3] deficiency hereditary afibrinogenemia Storage pool disorders: dense granule deficiencies Hermansky-Pudlak syndrome Wiskott-Aldrich syndrome thrombocytopenia with absent radii syndrome Chediak-Higashi syndrome DISORDERS OF PLATELET SECRETION (RELEASE) Hereditary thromboxane pathway disorders: aspirin-like defects cyclooxygenase deficiency thromboxane synthase deficiency Drug inhibition of the prostaglandin pathways drug inhibition of platelet phosphodiesterase activity uremia