agglutinin


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Related to agglutinin: cold agglutinin

Agglutinin

A substance that will cause a clumping of particles such as bacteria or erythrocytes. Of major importance are the specific or immune agglutinins, which are antibodies that will agglutinate bacteria containing the corresponding antigens on their surfaces. Agglutinins are readily determined, and their presence is of diagnostic value to indicate present or past host contact with the microbial agent sufficient to result in antibody formation. See Agglutination reaction, Antibody

Analogous reactions involve erythrocytes and their corresponding antibodies, the hemagglutinins. Hemagglutinins to a variety of erthyrocytes occur in many normal sera, and their amounts may be increased by immunization. The blood group isoagglutinins of humans and animals are important special cases which must be considered in all proposed blood transfusions lest transfusion reactions result. See Blood groups

agglutinin

[ə′glüt·ən·ən]
(immunology)
An antibody from normal or immune serum that causes clumping of its complementary particulate antigen, such as bacteria or erythrocytes.
References in periodicals archive ?
Effects of Complement Inhibition With Eculizumab Observed in Patients with Atypical Hemolytic Uremic Syndrome (aHUS) and Cold Agglutinin Disease (CAD)
Vicia faba agglutinin, the lectin present in broad beans, stimulates differentiation of undifferentiated colon cancer cells.
We prepared the multilectin column by mixing equal amounts of agarose-bound concanavalin A, agarose-bound wheat germ agglutinin, and agarose-bound Jacalin in an empty PD-10 disposable column (GE Healthcare).
In comparison to splenocytes and thymocytes proliferation of Abrus agglutinin and abrin (Ramnath et al.
Transferrin and apoC-III both showed abnormal IEF patterns, and peanut agglutinin lectin staining was increased in the fibroblasts.
In vitro influence of Phaseolus vulgaris, Griffonia simplicifolia, concanavalin A, wheat germ, and peanut agglutinins on HCT-15, LoVo, and SW837 human colorectal cancer cell growth.
Though we have not observed agglutinin properties of nebrodedolysin, there are some other proteins containing both agglutinin properties and hemolytic activity, such as Laetiporus sulphureus lectin (LSL).
The most successful approach has been based on the difference in the binding affinities of the AFP glycoforms to various lectins, particularly Lens culinaris agglutinin and concanavalin A (13-16).
Urtica dioica agglutinin (UDA), a lectin from stinging nettle roots, was reported to directly inhibit cell proliferation of Hela cells and block the binding of EGF to its receptor, and was regarded to be responsible for inhibiting effects in BPH treatment (Wagner et al.
Briefly, 2 [micro]L of serum was electrophoresed on a Lens culinaris agglutinin agarose gel and then blotted on a mouse anti-AFP-coated nitrocellulose membrane.
The effect was more pronounced than with wheat germ agglutinin, which possesses the same sugar specificity and the mannose-specific agglutinin Conconavalin A.
dichotoma agglutinin Sepharose columns) Lectin affinity chromatography CDT-TJA (separated on T.