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agglutinin |
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agglutinin [ə′glüt·ən·ən] (immunology) An antibody from normal or immune serum that causes clumping of its complementary particulate antigen, such as bacteria or erythrocytes. Agglutinin A substance that will cause a clumping of particles such as bacteria or erythrocytes. Of major importance are the specific or immune agglutinins, which are antibodies that will agglutinate bacteria containing the corresponding antigens on their surfaces. Agglutinins are readily determined, and their presence is of diagnostic value to indicate present or past host contact with the microbial agent sufficient to result in antibody formation. See Agglutination reaction, Antibody Analogous reactions involve erythrocytes and their corresponding antibodies, the hemagglutinins. Hemagglutinins to a variety of erthyrocytes occur in many normal sera, and their amounts may be increased by immunization. The blood group isoagglutinins of humans and animals are important special cases which must be considered in all proposed blood transfusions lest transfusion reactions result. See Blood groups How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| 05% Tween (TBS-Tw) with 5% bovine serum
albumin for 2 hours and then with Helix pomatia agglutinin (HPA)
biotinylated lectin, which recognizes Nacetyl-D-galactosamine (GalNAc),
a typical carbohydrate in O-glycans. Patients may also present with
lymphadenopathy, splenomegaly, hyperviscosity syndrome,
cryoglobulinemia, peripheral neuropathy, cold agglutinin hemolysis,
autoimmune thrombocytopenia, von Willebrand's disease and, in rare
cases, amyloidosis. The technology utilizes AIST's proprietary carbohydrate ligand
to detect even 15ng of ricin, 1/10,000 the amount of lethal dose, in
just 10 minutes, and, with combined use of three synthesized sugar
derivatives fixed on a toxin sensor chip, identifies RCA60 and RCA120,
similarly structured recin agglutinin. |
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