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agonist

   Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.01 sec.
agonist [′agĀ·ə‚nist]
(biochemistry)
A chemical substance that can combine with a cell receptor and cause a reaction or create an active site.
(physiology)
A contracting muscle that is resisted or counteracted by another muscle, called an antagonist, with which it is paired.


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Evidence that PPAR-[alpha] activation is a necessary and sufficient cause of rodent hepato-carcinogenesis supports PPAR-[alpha] activation as the sole mode of action (MOA) for these agents, and evidence that humans are relatively insensitive to this MOA have led some agencies to conclude that PPAR-[alpha] agonists do not contribute to human carcinogensis.
The ERalpha-selective agonist 4,4',4''-(4propyl-(1H)-pyrazole-1,3,5-triyl)trisphenol (PPT) stimulated proliferation.
The researchers have revealed that their study extends findings from two Mayo case series published in 2005, which reported a connection between dopamine agonist medications and compulsive gambling or hypersexuality.
 
 
 
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