One aspect of her research focuses on expression of genes as a result of exposure to alkylating agents
Hoping to shed some light on the rhyme and reason of all this activity, Samson and her colleagues decided to broaden the study to look at cells at various time points after exposure to a variety of alkylating agents
, including methyl methanesulfonate.
Published research suggests that the activity of a naturally occurring DNA repair enzyme called O6-methylguanine-DNA methyltransferase (MGMT) may be responsible for resistance to temozolomide and other alkylating agents
used in the treatment of GBM.
Major Alkylating Agents
Producer Output and Locations
Vion has two agents in Phase II clinical trials: Triapine(R), a potent inhibitor of a key step in DNA synthesis and CLORETAZINE(TM) (VNP40101M), a unique sulfonylhydrazine alkylating agent
The critical role of cleavable linkers for minor groove binding alkylating agent
(MGBA) based antibody-drug conjugates" (Abstract #1722), S.
Cloretazine(R) (VNP40101M) is a novel alkylating agent
which is also being evaluated in a pivotal Phase III trial in combination with cytarabine (Ara-C) for the treatment of patients of any age with relapsed AML.
It is activated in vivo to a bifunctional and trifunctional alkylating agent
In this market research, Frost & Sullivan's expert analysts thoroughly examine the following modalities: - targeted therapies - cytotoxics - cancer vaccines - other products (bone calcium regulators, cytotoxic antibiotics, anti-cancer agents, immunostimulants, alkylating agents
Group 8 - analogs, alkylating agents
Our study showed that these alkylating agents
are present at levels sufficient to cause DNA damage and could potentially have adverse implications to human health, particularly in the case of the development of oral cancer for BQ chewers," they said.
Overall, the literature suggests that 34% of females who undergo chemotherapy develop ovarian failure, though alkylating agents
such as cyclophosphamide are four times as toxic to the ovaries as other agents, Dr.