alkylation

(redirected from alkylating agent)
Also found in: Dictionary, Thesaurus, Medical, Legal, Financial, Wikipedia.

alkylation

[‚al·kə′lā·shən]
(chemical engineering)
A refinery process for chemically combining isoparaffin with olefin hydrocarbons.
(organic chemistry)
A chemical process in which an alkyl radical is introduced into an organic compound by substitution or addition.
References in periodicals archive ?
One aspect of her research focuses on expression of genes as a result of exposure to alkylating agents.
Hoping to shed some light on the rhyme and reason of all this activity, Samson and her colleagues decided to broaden the study to look at cells at various time points after exposure to a variety of alkylating agents, including methyl methanesulfonate.
Published research suggests that the activity of a naturally occurring DNA repair enzyme called O6-methylguanine-DNA methyltransferase (MGMT) may be responsible for resistance to temozolomide and other alkylating agents used in the treatment of GBM.
Major Alkylating Agents Producer Output and Locations
Vion has two agents in Phase II clinical trials: Triapine(R), a potent inhibitor of a key step in DNA synthesis and CLORETAZINE(TM) (VNP40101M), a unique sulfonylhydrazine alkylating agent.
The critical role of cleavable linkers for minor groove binding alkylating agent (MGBA) based antibody-drug conjugates" (Abstract #1722), S.
Cloretazine(R) (VNP40101M) is a novel alkylating agent which is also being evaluated in a pivotal Phase III trial in combination with cytarabine (Ara-C) for the treatment of patients of any age with relapsed AML.
In this market research, Frost & Sullivan's expert analysts thoroughly examine the following modalities: - targeted therapies - cytotoxics - cancer vaccines - other products (bone calcium regulators, cytotoxic antibiotics, anti-cancer agents, immunostimulants, alkylating agents and anti-metabolites).
Group 8 - analogs, alkylating agents nitrogen mustard
Our study showed that these alkylating agents are present at levels sufficient to cause DNA damage and could potentially have adverse implications to human health, particularly in the case of the development of oral cancer for BQ chewers," they said.
Overall, the literature suggests that 34% of females who undergo chemotherapy develop ovarian failure, though alkylating agents such as cyclophosphamide are four times as toxic to the ovaries as other agents, Dr.