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allopurinol

   Also found in: Dictionary/thesaurus, Medical, Wikipedia, Hutchinson 0.01 sec.
allopurinol [‚a·lə′pyür·ə‚nȯl]
(pharmacology)
C5H4ON4The compound 4-hydroxypyrazolo-3,4-d-pyrimidine; inhibits xanthine oxidase, an enzyme required for uric acid formation.


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At first, relapsed patients were treated with a combination of sodium stibogluconate and allopurinol, which was unsuccessful in contrast with its reported success in Kenya, or with amphotericin deoxycholate (8).
Yet one study showed that when rats were pretreated with allopurinol or superoxide dismutase/polyethylene glycol prior to the induction of ischemia, cochlear action potential thresholds were maintained.
If attacks continue and tophi develop, however, the doctor may prescribe medicine to treat hyperuricemia, most commonly allopurinol (Zyloprim) and probenecid (Benemid).
 
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