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allostery |
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allostery [′a·lō‚stir·ē]
(biochemistry) The property of an enzyme able to shift reversibly between an active and an inactive configuration. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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No references found | During the study, the researchers conducted trials with the help og potential drug candidate ADX10059, a negative mGluR5 allosteric modulator. INTRODUCTION Allosteric regulation of enzyme activity is widely used by living cells to control diverse physiological processes [1,2]. Coverage includes an introduction to signaling molecules and their receptors; an overview of the technical approaches to investigating these interactions; structural, functional, and pharmacological aspects of GPCRs; the analysis and interpretation of experimental data; the use of recombinant cell lines, receptor mutants and related artifices in drug research; and several trendy but often poorly understood concepts such as insurmountable antagonism, inverse agonism, and allosteric interactions. |
allosteric |
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