allotype

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Related to allotypic: allotypic determinants

allotype

[′a·lə‚tīp]
(immunology)
Inherited variations in the genes coding for certain amino acid sequences in the constant region of the immunoglobulin molecules.
(systematics)
A paratype of the opposite sex to the holotype.
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References in periodicals archive ?
Although allotypic epitopes can be expressed by many IgG molecules independent of their isotype, idiotopes that are formed by the variable region on the Fab portion mostly are unique epitopes.
As confirmed by similar observations of Vaidya and Beatty (16), polyclonal murine IgG prepared from many animals seems to be the best reagent to block interferences by such HAMAs because it will present all allotypic and cross-reactive idiotypic epitopes expressed on murine IgG molecules, whereas blocking reagents based on a single monoclonal antibody, such as MAK33, can be unsuitable when they are missing the respective epitopes.
In summary, our data demonstrate that, in patients treated repeatedly with the same monoclonal antibody, a considerable percentage of the HAMA response is directed against allotypic and cross-reactive idiotypic determinants.