lipoic acid

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lipoic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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Lipoic Acid


6,8-epi-dithio-octanoic acid, a widespread naturally occurring coenzyme, related to enzymes of the class of oxidoreductases. It exists in the form of crystals with melting point 59°-60°C and was first isolated from bull’s liver in 1941 (30 mg of lipoic acid was obtained from 10 tons of liver).

Lipoic acid participates in the transfer of acyl groups (acid radicals) and in biological oxidation reactions (for example, oxidative decarboxylation of pyruvic and ketoglutaric acids for conversion into acetyl-CoA and succinyl-CoA, respectively, with liberation of carbon dioxide). The oxidized form of lipoic acid is transformed into a reduced form, which is then reconverted into the oxidized form upon action of a specific enzyme:

Lipoic acid is the growth factor (vitamin) in certain microorganisms; it exists in composite protein form in the cells of plant and animal tissues.

lipoic acid

[lī′pō·ik ′as·əd]
C8H14O2S2 A compound which participates in the enzymatic oxidative decarboxylation of α-keto acids in a stage between thiamine pyrophosphate and coenzyme A.
References in periodicals archive ?
alpha lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats.
The plasma pharmacokinetics of oral doses of racemic alpha lipoic acid in healthy humans are known.
In the work with hepatic necrosis patients, I found alpha lipoic acid to be so effective in treating acute liver disease that I decided to explore its use for chronic conditions such as hepatitis C.
At BioLink we are actively developing alpha lipoic acid for clinical indications that are independent of InVasc's interests, and InVasc's work actually will help support the development of our products.
3% of women who received alpha lipoic acid and inositol, and a reduction in insulin resistance was observed in 66.
Marketed under the name Eternal Nutraceuticals (TM), the line is comprised of 10 different products containing quality ingredients that may include: Coenzyme Q10 ("CoQ-10"), Eicosapentaenoic Acid ("EPA"), Docosahexaenoic Acid ("DHA"), Ginkgo Biloba, Niacin, Alpha Lipoic Acid, Omega-3 (Fish Oil), Omega-6, Fennel Seed, Raspberry Ketone and Resveratrol, to name a few.
5 Both vitamin C and alpha lipoic acid have the ability to take away the extra electron from a used vitamin E molecule, effectively reactivating it.
RA7 contains soy, omega 3 fatty acids, CoQ10, alpha lipoic acid, green tea, Pycnogenol and vitamin A.
Researchers studied the effect of alpha lipoic acid (LA) on the protein collagen from high fructose-fed rat skin.
Alpha Lipoic Acid, Vitamin C Ester & DMAE Cream firms skin as it fights future skin damage with three unique ingredients in a soy liposome for deep penetration and time-release action.
Our Diabetic Vision Formula[TM] contains safe, clinically-proven ingredients, which include 11 different nutrients such as: Vitamin B-6, Omega-3, Niacin, Lutein, Alpha Lipoic Acid, Cinnamon Bark, Bilberry, and Grapeseed Extract," said Mr.
Overweight or obese individuals who received 1,800 mg of alpha lipoic acid daily for 20 weeks lost more weight compared with subjects who did not receive lipoic acid.