macrophage

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macrophage

[′mak·rə‚fāj]
(histology)
A large phagocyte of the reticuloendothelial system. Also known as a histiocyte.
References in periodicals archive ?
Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase1 by alveolar macrophages from patients with chronic obstructive pulmonary disease.
If the magnitude of exposure is low, and if the fibers are removed by alveolar macrophages, alveolar inflammation resolves.
However, similar to the effects observed in rats that chronically consume alcohol, dietary zinc supplementation restored GM-CSF signaling and alveolar macrophage phagocytic function in rats that were HIV-1 transgenic (Joshi et al.
Interleukin-10 secretion by alveolar macrophages and monocytes in sarcoidosis.
In concert with these defects in alveolar epithelial function, alcoholmediated suppression of alveolar macrophage immune functions are central to the increased risk for pneumonia.
In their study, Roney and Holian screened both forms of asbestos for their ability to stimulate alveolar macrophages from guinea pigs to produce superoxide anions.
Cells used in these experiments included primary human and rat alveolar macrophages, primary rat alveolar epithelial cells, and primary human airway epithelial cells.
Plausible biological mechanisms to explain the increased risk of smear-positive disease include poor alveolar macrophage antimicrobial activity in crack cocaine users due to decreased inducible nitric oxide synthase activity (13) and direct effects on the lung (10).
Alveolar macrophages (AM) form the first line of defense in the lung alveoli (1).
The researchers used a ubiquitous and potent opportunistic human bacterium, Pseudomonas aeruginosa, (4) to test for possible interaction between ash and this sample infectious agent in primary human airway epithelial cells, primary rat alveolar epithelial cells, and primary human and rat alveolar macrophages.
Alveolar macrophage and neutrophil numbers were estimated by counting ten different random fields from lung sections present in three different slides.
Additionally, cells exposed to cigarette smoke extract were treated with glucocorticoid, an anti-inflammatory drug commonly used to treat respiratory conditions, and results showed that the drug did not compensate for the impairment to the alveolar macrophage process caused by the cigarette smoke.