sarcoma

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sarcoma

(särkō`mə), highly malignant tumor arising in connective- and muscle-cell tissue. It is the result of oncogenes (the cancer causing genes of some viruses) and proto-oncogenes (cancer causing genes in human cells). It may affect bone, cartilage, blood vessels, lymph nodes, and skin. See cancercancer,
in medicine, common term for neoplasms, or tumors, that are malignant. Like benign tumors, malignant tumors do not respond to body mechanisms that limit cell growth.
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; neoplasmneoplasm
or tumor,
tissue composed of cells that grow in an abnormal way. Normal tissue is growth-limited, i.e., cell reproduction is equal to cell death. Feedback controls limit cell division after a certain number of cells have developed, allowing for tissue repair
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.

Sarcoma

 

a malignant tumor that consists of connective tissue. Mesenchymomas, which are sarcomas made up of embryonic connective tissue (mesenchyma), are distinguished from sarcomas made up of mature tissues of mesenchymal origin, for example, bone sarcomas (osteosarcomas), cartilaginous sarcomas (chondrosarcomas), vascular sarcomas (angiosarcomas), hematopoietic sarcomas (reticulosarcomas), muscular sarcomas (leiomyosarcomas, rhabdosarcomas), and sarcomas of skeletal nerve tissue (gliosarcomas).

Sarcomas constitute about 10 percent of all malignant tumors; they occur relatively more often in some African and Asian countries. The most common sarcomas are bone tumors and tumors of soft tissues, including muscular, vascular, and nerve tissues. Sarcomas of the hematopoietic organs occur less frequently. Histomorphologically, there are round-cell, polymorphocellular (sometimes giant-cell), and spindle-cell sarcomas, all of which differ in the shape and size of the cells, and fibrosarcomas, in which fibrous elements predominate over cellular elements.

All malignant tumors are characterized by growing into and destroying surrounding tissues; this property is especially pronounced in sarcomas. The early stages of cancers differ from the early stages of sarcomas; cancers metastasize to the nearest lymph nodes, while sarcomas usually spread by way of the bloodstream and frequently metastasize to remote organs.

The principles and methods of diagnosis, preventive measures, and treatment of sarcomas are the same as those used for other malignant tumors.

REFERENCE

Klinicheskaia onkologiia. Edited by N. N. Blokhin and B. E. Peterson, vols. 1–2. Moscow, 1971.

L. M. SHABAD

sarcoma

[sär′kō·mə]
(medicine)
A malignant tumor arising in connective tissue and composed principally of anaplastic cells that resemble those of supportive tissues.

sarcoma

Pathol a usually malignant tumour arising from connective tissue
References in periodicals archive ?
Alveolar soft part sarcoma most commonly presents between the ages of 10 and 35 years, with women being diagnosed on the average at 20 to 22 years and men at 27 to 30 years.
Alveolar soft part sarcoma is another rare tumor of uncertain histogenesis, most commonly diagnosed in the extremities of young adults, and with a tendency to metastasize.
2;q23) Argani et al, (16) 2007 Abbreviations: ASPL, alveolar soft part sarcoma locus; ASPS, alveolar soft part sarcoma; CLTC, clathrin heavy chain; NONO, non-POU domain-containing octamer-binding; PRCC, papillary renal cell carcinoma; PSF, polypyrimidine tract binding protein-associated splicing factor; RCC, renal cell carcinoma.
The 18-year-old was inspired by her former Cramlington Learning Village classmate Jessica Robson, who raised more than PS28,000 for TCT and the charity she set up in her own name before she lost her near four-year battle with alveolar soft part sarcoma in May.
84) Ultrastructural examination revealed the presence of numerous electron-dense, membrane-bound cytoplasmic granules, as well as membrane-bound rhomboid crystals identical to those found in alveolar soft part sarcoma.
Jessica Robson passed away in May following a near four-year battle with alveolar soft part sarcoma which began with her discovering a small lump in her right leg while on holiday.
Alveolar soft part sarcoma is a rare neoplasm of unknown histogenesis with poor prognosis.
All 8 cases of alveolar soft part sarcoma and 7 examples of extraskeletal myxoid chondrosarcoma failed to demonstrate ECAD or NCAD expression.
These cases included 1 axillary liposarcoma,[4] 1 leiomyosarcoma originating in the thigh,[4] 1 alveolar soft part sarcoma,[6] 3 malignant fibrous histiocytomas,[7-9] and 5 OSs.