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The protoplasm, whose ameboid character is more manifest than in the small cells.
But no trace of loosening of the endothelial membrane into single cells and of their isolation and rounding off as free ameboid elements and of their movement into the tissue could be found.
The only possible conclusion, therefore, seems to be that the ameboid mononuclear exudate cells rapidly accumulating in these early stages in the tissue are emigrated nongranular blood leukocytes, lymphocytes and monocytes.
As in the earlier stages, they do not become transformed into ameboid exudate cells.
Here again the most attentive search fails to show any signs of their supposed transformation into free ameboid cells either in the lumen or on the outer surface of the wall of the vessel.
There are no indications of a transformation of such receding endothelial cells into ameboid elements.
The quantity of the ameboid mononuclear exudate cells in the tissue during the present stages reaches its climax.
Whereas in the preceding stages there was a distinct gap between the local, large, mobilizing histiocytes (resting wandering cells) and the smaller, round (lymphocyte-like and monocyte-like) polyblasts of hematogenous origin, now the local histiocytes seem to have disappeared almost completely and the tissue contains, instead, great quantities of large ameboid, phagocytic cells, among which no distinction can be made as to their local or hematogenous origin.
10 Per) and to become transformed into histiocytes, which at once, under the influence of the inflammatory stimulation, develop further into ameboid polyblasts.
The pericytes, crowded full of carbon, probably under the influence of this stimulus, round off and transform themselves into large ameboid polyblasts (Fig.
The most important observation on the mildly irritated omentum in animals that received injections with India ink is the complete passivity of the endothelium in the process of production of the ameboid mononuclear phagocytic cells, the polyblasts.
If leukocytes of the blood of an adult rabbit are cultivated outside the body in a suitable nutritive medium, the lymphocytes as well as the monocytes in the course of a relatively short time are seen to develop into large, ameboid, phagocytic, carmine-storing polyblasts of the macrophage type; these cells also show a considerable capacity for mitotic proliferation.