Prospective studies and animal experiments are needed to improve the knowledge about amelogenesis
and MIH formation.
Imperfecta Several types of hypomature amelogenesis
imperfecta have been described.
Meanwhile, the researchers continue to study people with amelogenesis
imperfecta in families known to carry the tooth defect.
imperfecta (AI) is defined as a rare developmental hereditary abnormality caused by autosomal or X-linked dominant or recessive genes.
Novel ENAM mutation responsible for autosomal recessive amelogenesis
imperfecta and localised enamel defects.
A controlled study of dental development in amelogenesis
This association may be the result of the variation in timing, duration and severity of an insult or combination of insults affecting ameloblasts during the maturation stage of amelogenesis
[Jalevik et al.
Disturbances during the transitional and maturation stage of amelogenesis
result in pathologically soft (hypomaturated, hypomineralised) enamel of normal thickness.
imperfecta, fluorosis or chronological hypoplastic disturbances.
Concerning FS, Mathu-Muju and Wright  repeated a possibly valuable suggestion for pre-treatment that has been noted previously for defective enamel in amelogenesis
imperfecta cases by Venezie et al.
Imperfecta due to a mutation of the enamlin gene: Clinical case with genotype-phenotype correlations.
The demarcated opacity was not caused by caries, fluorosis or amelogenesis