amide hydrolysis


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amide hydrolysis

[′am‚īd hī′dräl·ə·səs]
(organic chemistry)
The cleavage of an amide into its constitutive acid and amine fragments by a net addition of water.
References in periodicals archive ?
Stanley Brown, FCIC, Queen's University: Catalysis Award for his research in electrophilic bromination, amide hydrolysis mechanisms, catalysis and model enzyme chemistry.
This, however must be followed by amide hydrolysis and equilibration at the benzylic centre, to give the threo isomer of the ritalinic acid.
Methods based on the chemical properties of amide groups in PAM, including: (A) fluorescence spectrometry; (B) amide hydrolysis with ammonia detection, and (C) N-bromination method.
22) suggested that the formation of DEA from alachlor in rats and monkeys is dependent upon the conjugation of alachlor to glutathione, consequent enterohepatic circulation of this reduced glutathione (GSH) conjugate, conversion of the GSH conjugate to the secondary methylsulfide, and amide hydrolysis of the secondary methylsulfide to DEA (22).