Stanley Brown, FCIC, Queen's University: Catalysis Award for his research in electrophilic bromination, amide hydrolysis
mechanisms, catalysis and model enzyme chemistry.
This, however must be followed by amide hydrolysis
and equilibration at the benzylic centre, to give the threo isomer of the ritalinic acid.
Methods based on the chemical properties of amide groups in PAM, including: (A) fluorescence spectrometry; (B) amide hydrolysis
with ammonia detection, and (C) N-bromination method.
22) suggested that the formation of DEA from alachlor in rats and monkeys is dependent upon the conjugation of alachlor to glutathione, consequent enterohepatic circulation of this reduced glutathione (GSH) conjugate, conversion of the GSH conjugate to the secondary methylsulfide, and amide hydrolysis
of the secondary methylsulfide to DEA (22).
The loss was apparently due to the amide hydrolysis