amide hydrolysis


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amide hydrolysis

[′am‚īd hī′dräl·ə·səs]
(organic chemistry)
The cleavage of an amide into its constitutive acid and amine fragments by a net addition of water.
References in periodicals archive ?
Stanley Brown, FCIC, Queen's University: Catalysis Award for his research in electrophilic bromination, amide hydrolysis mechanisms, catalysis and model enzyme chemistry.
22) suggested that the formation of DEA from alachlor in rats and monkeys is dependent upon the conjugation of alachlor to glutathione, consequent enterohepatic circulation of this reduced glutathione (GSH) conjugate, conversion of the GSH conjugate to the secondary methylsulfide, and amide hydrolysis of the secondary methylsulfide to DEA (22).