amodiaquine


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amodiaquine

[‚am·ō′dī·ə‚kwēn]
(pharmacology)
C20H22ClN3O A crystalline compound that melts at 208°C; used as an antimalarial.
References in periodicals archive ?
Shorter recrudescence time for F32-ART5 were consistently observed after a 48-h pulse of amodiaquine, mefloquine (Table 3, Figure 1,2, panels B, C, respectively) and chloroquine (Table 3; online Technical Appendix Figure 2).
Efficacy and safety of artemether + lumefantrine, artesunate + sulphamethoxypyrazine-pyrimethamine and artesunate + amodiaquine and sulphadoxine-pyrimethamine + amodiaquine in the treatment of uncomplicated falciparum malaria in Bangui, Central African Republic: A randomized trial.
Efficacy of artesunate plus amodiaquine versus that of artemether/lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania.
Amodiaquine plus sulphadoxine/pyrimethamine may be considered as an interim option where ACTs cannot be made available, provided that efficacy of both is high.
The Drugs for Neglected Diseases Initiative in March announced that ASAQ, a fixed-dose combination of artesunate and amodiaquine, will soon be available throughout the area where the majority of the deadly malaria cases hit.
It has also welcomed the development of combination drugs linking artemisinin with amodiaquine, lumefantrine, mefloquine or sulfadoxine-pyrimethamine, called ACTs.
In vitro micro-test (MARK 111) for the response of Plasmodium falciparum to cloroquine, mefloquine, quinine, amodiaquine, sulfadoxineipyrimethamine and arteminisin.
Artesunate, amodiaquine, artemether and lumefantrine powders were obtained from Ipca Laboratories Ltd.
In addition, the availability of non-recommended antimalarials such as amodiaquine caused prescription confusion.
For decades, chloroquine and its derivative amodiaquine have also been used as anti-inflammation drugs to treat diseases such as rheumatoid arthritis, though the exact mechanism of how chloroquine affects the immune system has remained unclear.
However, artesunate and amodiaquine are generally safe when used in treatment of malaria (20-22).
The combination of artesunate and amodiaquine will be known by the brand name Coarsucam in private sector sales.