amphotericin B


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Related to amphotericin B: liposomal amphotericin B

amphotericin B

(ăm'fətĕr`ĭsĭn), antibioticantibiotic,
any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. Types of Antibiotics
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 that halts the growth of several disease-causing fungi. Discovered in 1956, it is produced by bacteria of the genus Streptomyces. It is used in lotion or ointment form to treat fungal infections of the skin and is given internally only to patients with potentially fatal fungal infections. Amphotericin B is not effective against bacterial infections.

amphotericin B

[‚am·fə′ter·ə·sən ′bē]
(microbiology)
C46H73O20N The active component of amphotericin, suitable for systemic therapy of deep or superficial mycotic infections.
References in periodicals archive ?
Group F received saline loading along with acute nephrotoxic regimen of cyclosporine, amphotericin B infusion given on 5th day.
001) level of serum creatinine of group B receiving Amphotericin B as compared to control group A was seen.
Comparison of the early fungicidal activity of high-dose fluconazole, voriconazole, and flucytosine as second-line drugs given in combination with amphotericin B for the treatment of HIV-associated cryptococcal meningitis.
Antagonistic interactions between azoles and amphotericin B with yeasts depend on azole lipophilia for special test conditions in vitro.
The suggested order to continue therapy with lipid complex amphotericin B was incomplete.
Eight serial twofold dilutions of myrtle oil and amphotericin B was prepared and used in the MIC tests.
The extensive involvement of critical structures and the patient's frailty and unwillingness to undergo a disfiguring procedure precluded surgery, and we believed that her medical condition was too fragile to withstand IV amphotericin B therapy.
The occurrence of severe hyperphosphatemia during treatment with high-dose liposomal amphotericin was reported in a pediatric patient (3), but the possibility of pseudohyperphosphatemia caused by interference of liposomal amphotericin B in the phosphorus assay was not addressed.
Conventional amphotericin B deoxycholate has long been used, but is limited in efficacy and has significant toxicity.
Recent guidelines from the National Institute of Allergy and Infectious Diseases Mycoses Study Group and the Infectious Diseases Society of America suggest that life-threatening pulmonary or disseminated non-CNS disease, any CNS disease, and disease in the immunocompromised host be treated with amphotericin B to complete a total dose of 1.
Nystatin and amphotericin B in the treatment of denture-related candidiasis.