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amyloid beta protein

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amyloid beta protein [¦am·ə‚lȯid ¦bād·ə ′prō‚tēn]
(biochemistry)
A 42-amino-acid proteolytic product of the amyloid precursor protein that accumulates in the brains (frontal cortex and hippocampus) of persons with Alzheimer's disease.


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It is known that the cause of Alzheimer's is that overproduction of certain forms of amyloid beta protein by neurons leads to the generation of reactive oxygen species, which activate stress pathways.
The first published evidence that melatonin may be useful in Alzheimer''s disease was the demonstration that this neuro-hormone prevents neuronal death caused by exposure to the amyloid beta protein, a neurotoxin substance that accumulates in the brains of patients with the disorder.
In its changed form, elF2alpha increases the output of the enzyme that spurs production of the fiber-like knots of amyloid beta protein that form outside neurons and disrupt their ability to send messages.
 
 
 
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