anaphylatoxin


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anaphylatoxin

[¦an·ə‚fil·ə′täk·sən]
(immunology)
The vasodilator principal, a toxic substance released by tissues of sensitized animals when antigen and antibody react.
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Anaphylatoxin C5a receptor mRNA is strongly expressed in Kupffer and stellate cells and weakly in sinusoidal endothelial cells but not in hepatocytes of normal rat liver.
ASP is identical to C3adesArg, the inactive fragment of the complement anaphylatoxin peptide, C3a.
Role of C3, C5 and anaphylatoxin receptors in acute lung injury and in sepsis.
Furthermore, complement activation may potentiate platelet function (29, 30), as platelet activation and aggregation are directly induced by the anaphylatoxin complement C3a and its derivatives, which are activation products of complement C3 (31, 32).
12) Other non-immunologic stimuli including opiates, C5a anaphylatoxin, stem cell factor and some neuropeptides (e.
Anaphylatoxin C5a modulates hepatic stellate cell migration.
Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis.
CCX168, the company's orally-active small molecule antagonist, is designed to target the receptor for the pro-inflammatory protein known as 'complement 5a' (C5a), a so-called anaphylatoxin that drives inflammatory responses associated with autoimmune diseases such as vasculitis, aged-related macular degeneration, rheumatoid arthritis and related pathologies.
Several biologic interactions in the complement pathway that are likely to participate in acute asthma involve the C3a anaphylatoxin, a potent proinflammatory mediator generated early in inflammatory reactions by proteolytic cleavage of complement C3 (12).
The N-formyl peptide receptors and the anaphylatoxin C5a receptors: An overview.