anaphylatoxin


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anaphylatoxin

[¦an·ə‚fil·ə′täk·sən]
(immunology)
The vasodilator principal, a toxic substance released by tissues of sensitized animals when antigen and antibody react.
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CCX168, the Company's orally-active small molecule antagonist, is designed to target the receptor for the pro-inflammatory protein known as 'complement 5a' (C5a), a so-called anaphylatoxin that drives inflammatory responses associated with autoimmune diseases such as vasculitis, aged-related macular degeneration, rheumatoid arthritis and related pathologies.
Several biologic interactions in the complement pathway that are likely to participate in acute asthma involve the C3a anaphylatoxin, a potent proinflammatory mediator generated early in inflammatory reactions by proteolytic cleavage of complement C3 (12).
We identified these two peaks, with mass to charge ratios (m/z) of 9,100 and 10,100, as anaphylatoxin C3a and calgranulin A by additional mass spectral investigation using liquid chromatography coupled to mass spectrometry.
Objective: To search for anaphylatoxin activity in plasma during episodes of erythema marginatum, and to evaluate the histology of erythema marginatum by electron microscopy and immunohistologic techniques.
Dialysis leukopenia, hypoxemia, and anaphylatoxin formation: effect of membrane, bath, and citrate anticoagulation.
In protocol 1, the up-regulated peak 8126 Da corresponded to a C-terminal-truncated fragment of C3a anaphylatoxin [8126.
Aspirin-III blocks signals sent by both: immune complexes via FCR, and anaphylatoxin via C5 receptors.
C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease.
BC3 was subsequently determined to be the anaphylatoxin C3a lacking the C-terminal arginine (C3adesA,.