anaplasia


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Related to anaplasia: metaplasia

anaplasia

[‚an·ə′plāzh·ə]
(medicine)
Reversion of cells to an embryonic, immature, or undifferentiated state; degree usually corresponds to malignancy of a tumor.
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They are considered WHO grade II unless anaplasia, increased mitotic activity endothelial proliferations, and/or necrosis are present (Figure 4, C), in which case a diagnosis of anaplastic ependymoma, WHO grade III, is rendered, although clinical behavior is not well predicted by grade.
the epidermis, dermis and acini of the mammary gland appeared normal without any sign of anaplasia but there was an increase in granulation tissue, fat and small blood vessels (Figs.
Grade III (anaplastic) meningiomas are characterized by anaplasia, brain invasion, and [greater than or equal to] 20 mitoses per 10 HPF or are of the rhabdoid or papillary subtypes (Perry et al.
Las evaluaciones histopatologicas microscopicas permitieron revelar la presencia de tejido neoplasico maligno poco diferenciado de tipo linfoide, con predominio de linfocitos B con alto grado de anaplasia y areas de necrosis con hemorragias, ratificando el diagnostico de linfosarcoma multicentrico: Las celulas neoplasicas tenian escaso citoplasma, nucleos hendidos e hipercromaticos en conjunto con linfocitos pleomorficos y elevado indice mitotico; tambien se encontro celulas gigantes multinucleadas y necrosis, observandose un variado patron histologico en algunas areas del tejido tumoral (FIGS.
Las lesiones producidas en el epitelio en la gastritis, pueden convertirse en displasicas, constituyendo un terreno fertil para el desarrollo de anaplasia y carcinoma.
Neoplastic cells showed a high degree of anaplasia, high nucleus-to-cytoplasm ratio, usually one prominent nucleolus, partially condensed chromatin, and high mitotic index.
Entre los mesoteliomas malignos existe una variedad predominantemente epitelioide maligna, el cual es un tumor compuesto de celulas mesoteliales epitelioides con varios grados de anaplasia y crecimiento dentro del tejido fundamental, vasos linfaticos y sanguineos.
Se caracteriza tambien por la desdiferenciacion o perdida de la diferenciacion estructural y funcional de las celulas normales o anaplasia, constituyendo formaciones reguladas por leyes propias mas o menos independientes del organismo.
Parametros de diferenciacion para la clasificacion en grados del carcinoma epidermoide (1) Caracteristicas Bien Moderadamente diferenciado diferenciado Grado I Grado II Conservacion de los Si Regular estratos epiteliales Presencia de queratina Abundante Escasa Puentes intercelulares Bien formados Separandose Atipia celular Minima Grado creciente de anaplasia Actividad Minima Aumento de la actividad mitotica Caracteristicas Poco diferenciado Grado III Conservacion de los No estratos epiteliales Presencia de queratina No Puentes intercelulares Desaparecen Atipia celular Anomalias celulares extensas Actividad Grado severo (1) Launey y Land, 1986; Sapp et al.
We theorize that tumor anaplasia caused malignant myocytes to reexpress CK-MB and cTnT isoforms.
All of these tumor markers in conjunction with lymph-node-positive or lymphnode-negative status combined with the degree of histological anaplasia or with radiological findings of possible metastases define the stage of the disease or the severity of the malignancy.
Another characteristic of prostatic cancer cells is the degree of anaplasia or loss of structural differentiation, such as an increase in the nuclear/cytoplasmic ratio.