Suppression

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Related to androgen suppression: Androgen Deprivation Therapy, androgen ablation

suppression

[sə′presh·ən]
(computer science)
Removal or deletion usually of insignificant digits in a number, especially zero suppression.
Optional function in either on-line or off-line printing devices that permits them to ignore certain characters or groups of characters which may be transmitted through them.
(electronics)
Elimination of any component of an emission, as a particular frequency or group of frequencies in an audio-frequency of a radio-frequency signal.

Suppression

 

in genetics, a phenomenon that prevents the appearance of a character resulting from mutation and that causes partial or complete restoration of the normal phenotype.

Intragenic suppression is caused by a second (suppressor) mutation in the same gene in which the first (direct) mutation occurred. Intergenic suppression is caused by a second mutation in other genes that are located at a considerable distance from the suppressed gene. In intragenic suppression, a protein coded by a given gene can reacquire functional activity, although its original structure, in contrast to true reverse mutation, or reversion, is not restored. In intergenic suppression, the normal phenotype may be restored in some cases owing to mutations that permit other means of metabolism which do not require the functioning of the given gene. In other cases, the normal phenotype may be restored as a result of mutations that alter the process by which the genetic information of the mutant gene is realized.

The phenomenon of suppression, first discovered in 1920 by the American geneticist A. H. Sturtevant, is used to study the genetic code and other aspects of molecular genetics.

REFERENCE

Stent, G. Molekuliarnaia genetika. Moscow, 1974. Chapter 6. (Translated from English.)

I. I. TOLSTORUKOV

References in periodicals archive ?
He has been using intermittent androgen suppression for more than 5 years in his patients and said the difference in quality of life is striking for these men.
The researchers reported that the only significant side effects were related to the androgen suppression therapy.
Contents of this report include: Androgen Suppression Prostate Cancer & Prevention New Standard of Care Prostate and Obesity Company profiles
Celestia Higano at the University of Washington is conducting a Phase II study of exisulind in patients with prostate cancer who are being treated with intermittent androgen suppression.
21] on exercise and cancer determined that exercise is a safe and effective means of reducing many of the side effects associated with prostate cancer treatment and androgen suppression.
Influence of androgen suppression therapy for prostate cancer on the frequency and timing of fatal myocardial infarctions.
Causes of death in men undergoing androgen suppression therapy for newly diagnosed localized or recurrent prostate cancer.
3] In addition to the overt manifestations of androgen suppression, fundamental aspects of endocrine balance are altered through increased fat mass, which contributes to chronic comorbidities and may facilitate tumour progression.
The concept of similar efficacy between the two methods of androgen suppression has been challenged on the basis that an escape phenomenon occurs in some men treated with gonadotropin agonists and this results in an elevation of serum testosterone above castrate levels, potentially leading to unsatisfactory tumor control.
External irradiation with or without long term androgen suppression for prostate cancer with high metastatic risk: 10-year results of an EORTC randomised study.
Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): A phase III randomised trial.

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