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androgen
(redirected from androstane)

    Also found in: Medical, Wikipedia, Hutchinson 0.03 sec.
androgen (ăn`drəjən): see testosterone testosterone (tĕstŏs`tərōn), principal androgen, or male sex hormone .
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androgen

Any of a group of hormones that mainly influence the development of the male reproductive system. The main and most active androgen is testosterone, produced by cells in the testes. Androgens produced in smaller quantities, mainly by the adrenal gland but also by the testes, support the functions of testosterone. Androgens cause the normal changes of puberty in boys' bodies and then influence sperm-cell formation, sexual interest and behaviour, and male pattern baldness. Females produce trace quantities of androgens, mostly in the adrenal glands, as well as in the ovaries.
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These UGT isoforms are induced by aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), and pregnane-X receptor (PXR) agonists.
Thyroid-hormone--disrupting chemicals: evidence for dose-dependent ... by DeVito, Michael J. / Environmental Health Perspectives
The environmental pollutant 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene induces rat hepatic cytochrome P450 2B and 3A expression through the constitutive androstane receptor and pregnane X receptor.
Prenatal DDT exposure in relation to anthropometric and pubertal ... by Longnecker, Matthew P. / Environmental Health Perspectives
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors.
Conflicts of interest: Blumberg's response by Blumberg, Bruce / Environmental Health Perspectives
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