angiogenesis

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Related to angiogenic: angiogenic growth factors

angiogenesis

[¦an·jē·ō¦jen·ə·səs]
(embryology)
The origin and development of blood vessels.
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CAM assays have been widely used to study angiogenesis ([11]), and the advantages of the CAM model are as follows: (i) the highly vascularized nature of the CAM greatly promotes the assessment of angiogenic property; (ii) high reproducibility; (iii) simplicity and cost effectiveness; and finally (iv) as the CAM assay is a closed system, the half-life of many new molecules tends to be much longer in comparison to animal models, allowing experimental study of potential angiogenic compounds in small quantities ([12, 13]).
Despite these initial findings, still little is known about the biology of VEGF or of any other angiogenic factors in neurons, the signaling pathways that they activate and their functional role in neurodevelopment.
During the development of Zebrafish embryos, as the stage between 24 and 72 h post-fertilization (hpf) has the highest angiogenic activity, drugs are treated and evaluated using quantitative EAP assay (phosphatase substrate kit; Pierce, USA) at this stage according to the method of Huang et al.
In the hypoxia phase II, the ischemic retina produced angiogenic factors including VEGF, which further resulted in neovascularization.
VEGF is a key angiogenic growth factor and its level of expression is a critical marker for detection of diseases (29).
The mechanisms include the expression of angiogenic genes encoding soluble growth factors, regulatory molecules and extracellular molecules that protect endothelial tubules from damage from hypoxia.
These results suggest that 25-hydroxyvitamin D and angiogenic factors play independent roles in the pathogenesis of preeclampsia," said Dr.
There are four steps involved in the growth of blood vessels within tumors: i) the release of angiogenic growth factors by cancerous cells, ii) the disintegration of the basement membrane of a pre-existing capillary through the action of MMPs, iii) the proliferation and migration of endothelial cells to form sprouts, and iv) the formation of a capillary tube through the eventual contact of sprouts (Li et al.
Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors.
Angiocept is designed to work somewhat similarly to the already marketed angiogenic drug Avastin, made by Genentech Inc.
The aim of this paper is to review some of these angiogenic tumor markers.