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angiotensin
(redirected from angiotensin I)

   Also found in: Dictionary/thesaurus, Medical, Acronyms, Wikipedia 0.03 sec.
angiotensin [‚an·jē·ə′ten·sən]
(biochemistry)
A decapeptide hormone that influences blood vessel constriction and aldosterone secretion by the adrenal cortex. Also known as hypertensin.


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Normally, ACE converts the compound angiotensin I into angiotensin II, which induces the blood vessels to constrict and blood pressure to rise.
[17] A fall in blood pressure causes renin to be released from the kidneys, which catalyzes the conversion of angiotensinogen to angiotensin I.
Renin, a highly specific aspartyl protease, cleaves angiotensinogen, to yield angiotensin I, which is further converted into angiotensin II by ACE (Angiotensin Converting Enzyme).
 
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