angiotensin

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angiotensin

[‚an·jē·ə′ten·sən]
(biochemistry)
A decapeptide hormone that influences blood vessel constriction and aldosterone secretion by the adrenal cortex. Also known as hypertensin.
References in periodicals archive ?
The team did not prove that the angiotensinogen gene itself triggers the elevated pressures.
Components of the renin--angiotensin system, including angiotensinogen (AGT), angiotensin-converting enzyme (ACE), and type 1 angiotensin II receptor (AGTRI) genes, have well-described impacts on inflammation, blood pressure, and vasoconstriction (Gradman 2009) that are mediated in part via G protein--coupled receptor kinases (GRKs), including GRK4 (Felder and Jose 2006).
In the treatment of hypertension, plasma renin activity (PRA) [2] assay is used to assess the capacity of circulating renin and angiotensinogen to generate the pressor peptide angiotensin (Ang) II via quantitative analysis of the upstream peptide precursor Ang I.
Aiwu Zhou and colleagues decided to focus on angiotensin's parent molecule, angiotensinogen.
Blood pressure is linked to salt intake and modulated by the angiotensinogen gene in normotensive and hypertensive elderly subjects.
The findings, published in the journal Nature, showed that angiotensinogen is oxidised and changes shape to permit access by the enzyme renin.
In the obese state, the expression of adipocytokines such as resistin, interleukin-6 (IL-6), tumor necrosis factor-[alpha] (TNF-[alpha]), plasminogen activator inhibitor-1 (PAI-1), monocyte chemotactic protein-1 (MCP-1), and angiotensinogen is increased in enlarged adipocytes, causing insulin resistance and metabolic disorders.
Ln the classic PRA assay the angiotensinogen and renin are endogenous, thus it is not possible to use a renin calibrator in this format.
A protease produced in the kidneys, renin cleaves angiotensinogen which is ultimately converted to angiotensin II, bringing about sodium retention and an increase in blood pressure.

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