nonsteroidal anti-inflammatory drug

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nonsteroidal anti-inflammatory drug,

a drug that suppresses inflammation in a manner similar to steroidssteroids,
class of lipids having a particular molecular ring structure called the cyclopentanoperhydro-phenanthrene ring system. Steroids differ from one another in the structure of various side chains and additional rings. Steroids are common in both plants and animals.
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, but without the side effects of steroids; commonly referred to by the acronym NSAID (ĕn`sĕd). Also effective in alleviating pain and fever, NSAIDs are commonly used to treat the symptoms of arthritis, gout, bursitis, painful menstruation, and headache. They act by inhibiting the synthesis of prostaglandins, leukotrienes, and other compounds that are involved in the inflammatory process.

Aspirin is technically an NSAID, but the term is often used to refer to nonaspirin products. The first nonaspirin NSAIDs were introduced in 1964. Common NSAID products include diclofenac (Cataflam, Voltaren), indomethacin (Indocin), ketorolac (Acular, Toradol), and piroxicam (Feldene). Ibuprofenibuprofen
, nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, fever, and inflammation. Along with naproxen and ketoprofen, ibuprofen belongs to the propionic acid class of NSAIDs. It was first made available in 1967.
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, naproxennaproxen
and naproxen sodium,
potent nonsteroidal anti-inflammatory drugs (NSAID) used to alleviate the minor pain of arthritis, menstruation, headaches, and the like, and to reduce fever.
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, and ketoprofenketoprofen
, nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and fever-reducing effects, used to relieve the symptoms of headaches, arthritis, and painful menstruation.
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 are available as over-the-counter drugs in the United States. The cox-2 inhibitors, such as celecoxib (Celebrex), selectively inhibit clooxygenase-2 (cox-2), an enzyme that causes pain and inflammation in arthritic joints, but do not interfere with cox-1, which protects the stomach and intestinal lining from ulceration. Very common drugs, NSAIDs are taken daily by an estimated 3 million Americans.

Although they are often considered easier to tolerate than aspirin, and most do not have as strong an anticlotting effect as aspirin, NSAIDS can have serious side effects, particularly gastrointestinal ulcers and upper gastrointestinal tract bleeding and perforation in those who take the drugs on a regular basis. NSAID-related gastropathy results in more than 2,000 deaths in the United States each year.

References in periodicals archive ?
In contrast to other immune therapies this does not lead to a weakening of the immune system, but rather enables the cells instead to be anti-inflammatory if needed, without losing the ability to fight dangerous pathogens.
Arthritis indication was the major revenue generating segment in the global anti-inflammatory therapeutics market in 2014 followed by respiratory diseases
Lastly, in a double-blind placebo-controlled examination of 32 males, ages 18 to 35, a topical non-steroidal anti-inflammatory drug (NSAID) appeared effective.
Sometimes the discomfort only can be reached by the fingers of anti-inflammatory drugs.
US Patent 7,846,744, titled, "Methods of Identifying Anti-Inflammatory Compounds," covers the use of human receptor DC-SIGN (or mouse SIGN-R1) to screen for drugs that either suppress or activate anti-inflammatory activity.
Exhaustive analysis of the global anti-inflammatory therapeutics market by product type helps in understanding the types of therapeutics that are currently being used along with the categories that would gain prominence in the future.
The other study tested the effects in rats of a statin called atorvastatin (Lipitor) combined with an anti-inflammatory drug.
In a recent study, 222 adults who had suffered a minor, painful sports injury within the past 72 hours were recruited for a multicenter, randomized, placebo-controlled, parallel design trial to determine the efficacy of an NSAID patch--topical anti-inflammatory medication applied directly to the injury site.
The results of this preclinical study, said Enzo, demonstrate that Enzo's immune enhancement regulation technology could be effective in negating the effects of GvHD by enhancing the anti-inflammatory immune response mounted by the donor tissue or cells.
LONDON & NEW YORK -- Morria Biopharmaceuticals Plc, a biopharmaceutical company focused on novel, anti-inflammatory drugs, announced today that it will be presenting the results from its ICH compliant Phase II study of MRX-4 (n=105) in patients suffering from allergic rhinitis at the upcoming 29th EAACI Congress (European Academy of Allergy and Clinical Immunology) in London on June 7th.
Taking over-the-counter anti-inflammatory drugs can cut a smoker's likelihood of developing mouth cancer, a study from Norway suggests.
Beyond this simple statement of the obvious, there is very little definitive proof of the effectiveness of other widely accepted treatments and prevention advice--ice, anti-inflammatory medications, strength, and flexibility.