This is especially true if the deviation occurs at the antibody binding site
This mechanism of action has been validated by experiments with single-chain antibody fragments containing the antibody binding site
The new patent is much broader and now claims the use of any antibody that recognizes or binds to the epitope, an antibody binding site
on the TpP protein, that is recognized by MH-1 or 45J.
The changes turn out to be on the virus surface, suggesting very strongly, says Hogle, "that the site of the mutation represents the antibody binding site
The latter has facilitated the development of light-scattering assays for haptens and other relatively low-molecular-mass analytes (<5000 Da and only providing one viable antibody binding site
per molecule) by using the principle of immunoinhibition .
Specifically, the new data presented identifies E4G10's unique antibody binding site
on VE-cadherin, which is a region on the protein that is necessary for VE-cadherin function.
The patent covers humanized antibodies which, in addition to containing the mouse antibody binding site
(complementarity determining regions, or CDRs) transferred to a human antibody, also contain one or more amino acid substitutions from the mouse antibody into the humanized antibody framework (that is, into the portion of the antibody adjacent to the CDRs).
The genetic engineering of fusion proteins bearing an antibody binding site
specific for tumor cells and a toxin that enzymatically blocks protein synthesis represents an exciting class of therapeutic agents for the treatment of cancer," said Dr.
Practically, if one uses antibodies with known MESF values, which are assigned using the same methodology for obtaining MESF values of beads, the number of antibody binding sites
per cell is equal to the ratio of the MESF value per cell and the MESF value per antibody.
These biosensors can be applied for direct detection or in a competitive immuno-biosensor format where a labeled antigen competes with the analyte for the antibody binding sites
When a "sensor" or "capture" antibody (or other binding agent) is introduced into an analyte-containing medium, sensor antibody binding sites
are occupied by analyte molecules to a fractional extent that reflects both the equilibrium constant governing the binding reaction and the final unbound analyte concentration in the mixture.
In particular, he has made major contributions to understanding the functional importance of the amino acid composition of antibody binding sites