antifibrinolysin

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antifibrinolysin

[¦an·tē‚fī·brə′näl·ə·sən]
(biochemistry)
Any substance that inhibits the proteolytic action of fibrinolysin.
References in periodicals archive ?
The efficacy of antifibrinolytic therapy was further demonstrated when the effect of TXA versus placebo was examined in trauma patients with, and at risk of, significant bleeding.
Fibrinolysis is investigated either by the measurement of its individual components (pro- and antifibrinolytic drivers) or through global tests designed to assess the time for clot dissolution upon addition of optimal amounts of tPA.
A shift in balance between profibrinolytic and antifibrinolytic factors causes enhanced fibrinolysis in cirrhosis.
Cell salvage, antifibrinolytic agents and preoperative erythropoietin (EPO), with or without iron, have all been shown to reduce blood transfusion requirements in paediatric craniofacial surgery (5,6,17,20,22).
8) Nevertheless, because of its antifibrinolytic effect, tranexamic acid is contraindicated in woman with an increased risk of thromboembolism and should be used concomitantly with oral contraceptives only if absolutely necessary.
Antifibrinolytic agents are used in patients undergoing major surgery in order to prevent fibrinolysis and minimize blood loss.
The use of antagonists, such as protamine sulfate for heparin, vitamin K1 for warfarin, and antifibrinolytic drugs for thrombolytic agents, may be necessary in treating hemorrhagic events.
Antifibrinolytic agents such as tranexamic acid and [epsilon]-aminocaproic acid have also been used for routine prophylaxis.
It shows substantial hyperfibrinolysis, which can lead to possible treatment with antifibrinolytic agents.
0 million for a controlling interest in a Hong Kong company that holds a license over two of QRxPharma's lead haemostasis product candidates: Textilinin, an antifibrinolytic agent, and HaempatchTM, a potent pro-coagulant.