Antimalarial

(redirected from antimalarial drug)
Also found in: Dictionary, Thesaurus, Medical, Wikipedia.
Related to antimalarial drug: Plaquenil

antimalarial

[‚an·tē·mə′ler·ē·əl]
(pharmacology)
A drug, such as quinacrine, that prevents or suppresses malaria.
Acting against malaria.

Antimalarial

 

a medicinal preparation for the treatment and prophylaxis of malaria. Antimalarials are classified into several groups according to their selective or predominant effect on various forms of plasmodia. For example, quinacrine hydrochloride, chloroquine, and quinine kill schizonts in the blood and rapidly curtail malarial attacks, while quinocide and primaquine destroy malarial parasites in tissues and prevent future relapses of tertian and quartan malaria. For this reason, drugs of both groups are usually used with the above forms of malaria. Proguanil hydrochloride acts on the erythrocytic and sexual forms of plasmodia; it is especially effective against the pathogen that produces falciparum malaria. Quinocide and primaquine also kill the gamonts of pathogens and, as a result, the infected person remains noninfective for the mosquito. Quinine is usually used in regions where the pathogens that produce falciparum malaria are resistant to chloroquine. The administration of antimalarials, such as chloroquine, to healthy individuals is used in the chemoprophylaxis of malarial foci.

Most antimalarials are obtained synthetically. Quinine, for example, is an alkaloid of a cinchona tree. Antimalarials are also used to treat certain diseases caused by protozoans or helminths; for example, quinacrine hydrochloride is used to treat amebiasis, giardiasis, and leishmaniasis, while pyrimethamine is used to treat toxoplasmosis.

REFERENCE

Moshkovskii, Sh. D., ed. Ukazaniia po lecheniiu i khimioprofilaktike maliarii. Moscow, 1972.

N. N. PLOTNIKOV

References in periodicals archive ?
anthotheca, showed potent antimalarial activity using a [(3)H]-hypoxanthine and 48h culture assay in vitro, when compared with other natural limonoids and currently used antimalarial drugs.
Strategies for the prevention of antimalarial drug resistance: Rationale for combination therapy for malaria.
World Health Organization: Antimalarial drug combination therapy: Report of WHO technical consultation.
Monitoring antimalarial drug resistance: making the most of the tools at hand.
Many approaches to antimalarial drug discovery are available (Ridley, 2002; Rosenthal, 2003; Fidock et al.
2) In many African countries, the ready availability of antimalarials without prescription, and incompleted treatment courses, contribute to drug pressure, and the range of antimalarial drug options is limited.
Diabetes risk decreased by as much as 77% in patients who took the antimalarial drug hydroxychloroquine for more than 4 years, "a finding that is comparable or superior to that of other drugs studied in clinical trials: rosiglitazone, combination hormone therapy, estrogen [only], metformin, acarbose, and ramipril," the study researchers reported.
When he contracted malaria last week, she gave him Fansidar, a commonly prescribed antimalarial drug here.
Challenges in antimalarial drug discovery Jeremy N Burrows, et al.
This resistance became a global problem during the 1960s, when Plasmodium falciparum parasites developed resistance to chloroquine, the most widely used antimalarial drug at that time (3).
Today, Novartis published clinical trial results in the New England Journal of Medicine showing that KAE609 (cipargamin), a novel and potent antimalarial drug candidate, cleared the parasite rapidly in Plasmodium falciparum (P.
Artemisinin (called QingHaoSu in Chinese, also short for QHS), is an antimalarial drug used as a treatment for fever and malaria from Chinese traditional medicine and used in China for many centuries (1).