antimetabolite


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Related to antimetabolite: methotrexate

antimetabolite:

see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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antimetabolite

[¦an·tē·mə′tab·ə‚līt]
(pharmacology)
A substance, such as sulfanilamide or amethopterin, that inhibits utilization of an essential metabolite because it is an analog of the metabolite.
References in periodicals archive ?
Pemetrexed, originally developed by Eli Lilly and Company, is a multi-targeted antimetabolite antitumor drug.
RX-3117 is a small molecule antimetabolite for the treatment of solid tumors.
The current malignant mesothelioma therapeutics market is dominated by the chemotherapeutic regimen, Alimta (pemetrexed), which is a folate antimetabolite in combination with cisplatin.
announced on May 31 that a global Phase III clinical trial (RECOURSE) for the novel combination antimetabolite TAS-102 will start in June this year.
Then the prodrug-activating enzyme produced in the cancer cell activates orally administered Toca FC, an extended-release formulation of 5-fluorocytosine (5-FC), into a powerful antimetabolite, 5-FU, selectively in the cancer cell.
A member of the fluoropyrimidine class of chemotherapeutic agents, Teysuno is a combination of three pharmacological compounds: tegafur, an antimetabolite agent that, after absorption, is converted into the anti-cancer agent fluorouracil (5-FU); gimeracil (5-chloro-2, 4-dihydroxypyridine, or CDHP), which decreases the degradation of 5-FU by the body; and oteracil (Oxo), which decreases 5-FU activation in the gastrointestinal tract.
Although the antimetabolite gemcitabine is the most common first-line drug for the treatment of this disease, it does not prolong overall survival.
Then the prodrug-activating enzyme produced in the cancer cell activates orally administered Toca FC given in cycles, into a powerful antimetabolite, 5-FU, selectively in the cancer.
As a multi-targeted antimetabolite antitumor drug, pemetrexed can treat non-small cell lung cancer, pancreatic cancer and breast cancer with little side effect.
Browse the full Non Small Cell Lung Cancer Therapeutics Market: (By Drug Class: Angiogenesis Inhibitor, EGFR Inhibitor, Kinase Inhibitor, Microtubule Stabilizer, Folate Antimetabolites, and PD-1/PD-L1 Inhibitor): Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2015 - 2023 report at http://www.
Antimetabolites Aminopterin * + + / [+ or -] + Azathioprine 0 0 5-fluorouracil * + + + / + + + Methotrexate * + + / [+ or -] 0 Thioguanine + + No activity shown by cytarabine, mercaptopurine.