Pemetrexed, originally developed by Eli Lilly and Company, is a multi-targeted antimetabolite
RX-3117 is a small molecule antimetabolite
for the treatment of solid tumors.
The current malignant mesothelioma therapeutics market is dominated by the chemotherapeutic regimen, Alimta (pemetrexed), which is a folate antimetabolite
in combination with cisplatin.
announced on May 31 that a global Phase III clinical trial (RECOURSE) for the novel combination antimetabolite
TAS-102 will start in June this year.
Then the prodrug-activating enzyme produced in the cancer cell activates orally administered Toca FC, an extended-release formulation of 5-fluorocytosine (5-FC), into a powerful antimetabolite
, 5-FU, selectively in the cancer cell.
A member of the fluoropyrimidine class of chemotherapeutic agents, Teysuno is a combination of three pharmacological compounds: tegafur, an antimetabolite
agent that, after absorption, is converted into the anti-cancer agent fluorouracil (5-FU); gimeracil (5-chloro-2, 4-dihydroxypyridine, or CDHP), which decreases the degradation of 5-FU by the body; and oteracil (Oxo), which decreases 5-FU activation in the gastrointestinal tract.
Although the antimetabolite
gemcitabine is the most common first-line drug for the treatment of this disease, it does not prolong overall survival.
Then the prodrug-activating enzyme produced in the cancer cell activates orally administered Toca FC given in cycles, into a powerful antimetabolite
, 5-FU, selectively in the cancer.
Rasuvo should be used only by physicians whose knowledge and experience include the use of antimetabolite
As a multi-targeted antimetabolite
antitumor drug, pemetrexed can treat non-small cell lung cancer, pancreatic cancer and breast cancer with little side effect.
Browse the full Non Small Cell Lung Cancer Therapeutics Market: (By Drug Class: Angiogenesis Inhibitor, EGFR Inhibitor, Kinase Inhibitor, Microtubule Stabilizer, Folate Antimetabolites
, and PD-1/PD-L1 Inhibitor): Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2015 - 2023 report at http://www.
Aminopterin * + + / [+ or -] + Azathioprine 0 0 5-fluorouracil * + + + / + + + Methotrexate * + + / [+ or -] 0 Thioguanine + + No activity shown by cytarabine, mercaptopurine.