antimetabolite


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Related to antimetabolite: methotrexate

antimetabolite:

see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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antimetabolite

[¦an·tē·mə′tab·ə‚līt]
(pharmacology)
A substance, such as sulfanilamide or amethopterin, that inhibits utilization of an essential metabolite because it is an analog of the metabolite.
References in periodicals archive ?
Besides corticosteroids, long-term treatment options for the treatment of JIA-associated uveitis include antimetabolites, alkylating agents and biologic agents.
Arginine antimetabolite L-canavanine induces apoptotic cell death in human Jurkat T cells via caspase-3 activation regulated by Bcl-2 or Bd-xL.
However similar results may not be obtainable in higher risk eyes without the use of antimetabolites as the only demonstrable risk factor for failure in our patients was the prior use of topical medications.
Topical 5-FU is an antineoplastic antimetabolite that is applied twice daily to the lesion.
One-quarter had received antimetabolite therapy in the past.
Methotrexate is an antimetabolite that penetrates the blood brain barrier when given in high doses intravenously.
Prospective, randomized, controlled trials are currently underway to formulate evidence-based algorithms for the initiation of antimetabolite therapy in IBD.
It compared the continuation of cyclophosphamide after disease remission to "step-down" to an antimetabolite with fewer side effects, azathioprine.
The list of other associated adverse health effects include: (a) antimetabolite affecting every organ; (b) endocrine disruptor; (c) increased risk of diabetes mellitus; (d) neurotoxicity: (e) hyperkeratosis; (f) skin pigmentation; (g) hepatotoxictiy; (h) cardiovascular disease; (i) peripheral vascular disease; and (j) diminished hearing (American Academy of Pediatrics [AAP], 2003; Centeno et al.
ALLs with hyperdiploidy with >50 chromosomes in children are highly sensitive to antimetabolite drugs and have a complete remission rate approaching 100% with an ~80% long-term disease-free survival (9).
Azathioprine is the generic equivalent to Imuran, an immunosuppressive antimetabolite manufactured by Glaxo Wellcome Inc.