antioncogene


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antioncogene

[¦an·tē′aŋ·kə‚jēn]
(genetics)
Any of a class of genes that are involved in the negative regulation of normal growth; the loss or mutation of these genes leads to malignant growth. More generally called tumor suppressor gene.
References in periodicals archive ?
The discovery of oncogenes (tumor-causing genes) and antioncogenes (tumor-suppressing genes) has fueled the search for genes involved in the development of prostate cancer.
The concept of tumor-suppressor genes or antioncogenes was developed in the 1970s; these genes are believed to function as recessive genes.
Antioncogenes A tumor-suppressing gene involved in controlling cellular growth; deactivation of this type of gene leads to unregulated cell growth as in cancer.