antisense


Also found in: Dictionary, Thesaurus, Medical, Wikipedia.
Related to antisense: Antisense strand, Antisense drugs

antisense,

DNA or RNA manipulated in a laboratory so that its components (nucleotides) form a complementary copy of normal, or "sense," messenger RNA (mRNA; see nucleic acidnucleic acid,
any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
..... Click the link for more information.
). Antisense techniques are used to deactivate disease-causing or undesirable genes so that they cannot produce harmful or unwanted proteins. (Conventional drugs bind directly with disease-causing protein molecules, but their imperfect specificity may lead them to bind with other protein molecules, resulting in unwanted side effects. Antisense molecules are extremely specific.) In some applications of this technique, the antisense nucleic acid segment is inserted into an inactivated or nonvirulent virus, then introduced into the cell. The antisense segment pairs with the mRNA, preventing the synthesis of protein by the mRNA. Antisense has applications in agricultural biotechnology, where it has been used to deactivate the gene that causes softening in tomatoes, and in medicine, especially in cancer and antiviral therapy. See also gene therapygene therapy,
the use of genes and the techniques of genetic engineering in the treatment of a genetic disorder or chronic disease. There are many techniques of gene therapy, all of them still in experimental stages.
..... Click the link for more information.
.

antisense

[¦an·tē′sens]
(genetics)
A strand of deoxyribonucleic acid having a sequence identical to messenger ribonucleic acid.
References in periodicals archive ?
The OncoGenex and Isis partnership combines OncoGenex' proprietary antisense position in inhibitors to the target, clusterin, with Isis' proprietary second-generation antisense chemistry called 2'-O-methoxyethyl.
Antisense Therapeutics has a strategic partnership with Isis Pharmaceuticals , which is also a major shareholder in the Company.
The promise of antisense drugs lies in the theory that they work on a specific target disease without causing significant side effects.
Under the terms of the agreement, AVI is granting Eleos an exclusive license to AVI's NEUGENE([R]) third-generation antisense chemistry to treat cancer with p53-related drugs.
ATL1101 is a second-generation antisense drug designed to block the synthesis of the IGF-1 receptor, a protein involved in the regulation of cell overgrowth in psoriasis.
However, even though they gave higher doses of the antisense material to some patients, the researchers have not yet achieved a high enough concentration of this drug in the blood.
This partnership with DTRA and the DoD serves as validation of AVI's proprietary NEUGENE([R]) antisense approach to gene silencing in general, as well as specific confirmation of AVI's concept of rapid response therapeutics," said Alan P.
The Canadian patent application covers Enzo's pioneering technology for antisense RNA.
The study, entitled "Blocking of Heart Allograft Rejection by Intercellular Adhesion Molecule-1 Antisense Oligonucleotides Alone or in Combination with Other Immunosuppressive Modalities," was published in the Dec.
Like DNA, antisense molecules carry much more information than a typical drug molecule, says Stanley T.
Nasdaq:AVII), today announced human clinical trial results showing that three distinct NEUGENE([R]) antisense drugs entered the cerebral spinal fluid (CSF) of healthy adult male volunteers following a single 100 mg dose via intravenous (IV) or subcutaneous (subq) injections.
29 /PRNewswire/ -- Isis Pharmaceuticals (Nasdaq: ISIP) announced publication of results of a study showing the selective inhibition of gene expression by antisense compounds.