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Related to antithymocyte globulin: cyclosporine, Atgam, antithymocyte globulin equine


any of a large family of proteinsprotein,
any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. Protein comprises approximately 50% of cellular dry weight.
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 of a spherical or globular shape that are widely distributed throughout the plant and animal kingdoms. Many of them have been prepared in pure crystalline form. The term globulin is a partly procedural one, used in classifying an otherwise diverse group of proteins that are soluble in water or dilute salt solutions. Among the most important are the immunoglobulins (Ig), the antibodies of the immune system (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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). They are classified into five types based upon structure: IgA, IgD, IgE, IgG, and IgM. IgG or &ggr;-globulin is the most common and forms about 70% of the immunoglobins in the blood. Other globulins are involved in the transport of a variety of substances, including lipidslipids,
a broad class of organic products found in living systems. Most are insoluble in water but soluble in nonpolar solvents. The definition excludes the mineral oils and other petroleum products obtained from fossil material.
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, hormoneshormone,
secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue.
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, and inorganic ions.


A general name for any member of a heterogeneous group of serum proteins precipitated by 50% saturated ammonium sulfate. See Protein, Serum

The introduction of electrophoresis during the 1930s permitted subdivision of the globulins into alpha, beta, and gamma globulins on the basis of relative mobility at alkaline pH (8.6). However, each of these subgroups, though electrophoretically homogeneous, consists of a great variety of proteins with different biological properties and markedly different sizes and chemical properties other than net charge. Thus the α2-globulins, for example, as defined by moving boundary or paper electrophoresis, contain proteins ranging in molecular weight from approximately 50,000 to approximately 1,000,000 (α2-macroglobulin), each with differing functions. See Immunoglobulin


A heat-labile serum protein precipitated by 50% saturated ammonium sulfate and soluble in dilute salt solutions.


any of a group of simple proteins, including gamma globulin, that are generally insoluble in water but soluble in salt solutions and coagulated by heat
References in periodicals archive ?
2'3" Immunosuppressive regimens have emerged over the years with varying responses to regimens that include antithymocyte globulin through high-dose corticosteroids and cyclosporin or novel agents.
She received alemtuzumab with her first allogeneic transplant and conditioning with antithymocyte globulin before her second transplant, resulting in significant in vivo T-cell depletion; she was also receiving adrenal corticosteroids.
Low IPSS score and bone marrow hypocellularity in MDS patients predict hematological responses to antithymocyte globulin.
3) Treatment of MAS in patients with systemic onset JRA has included a variety of chemotherapeutic and immunosuppressive agents such as high-dose corticosteroids, cyclosporin, cyclophosphamide, antithymocyte globulin and IV immunoglobulin.
Antithymocyte globulin targets CD3 and other cellular proteins, and tests of diabetic mice have suggested that it reverses the disease.
Intravenous antithymocyte globulin also was given for 10 days, ultimately leading to resolution of the rejection (Lancet 355[9203]:548-49, 2000).
Table 18: Antithymocyte globulin (ATG) available in the US and EU, 2007 58
He was then treated with a 10-day course of antithymocyte globulin (Atgam) for presumed chronic rejection and also had a tracheostomy because of prolonged respiratory failure.