apomorphine


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Related to apomorphine: Apomorphine hydrochloride

apomorphine

[¦ap·ə¦mȯr‚fēn]
(pharmacology)
C17H17NO2 A crystalline alkaloid obtained by dehydration of morphine; acts as a powerful emetic.
References in periodicals archive ?
Apomorphine sublingual film is being developed to treat all types of motor OFF episodes, characterized, in part, by tremor, stiffness or slow movement, that may disrupt a person's ability to perform everyday activities and are burdensome for patients, family and caregivers.
Apomorphine increased motor activity monitored in a familiar environment and apomorphine-induced behavioural sensitisation was more potentiated in animals previously exposed to unpredictable chronic mild stress as they showed more cage crosses after 2nd and 3rd (p<0.
This decrease in activity was reversed by the dopamine agonist apomorphine, suggesting that the behavioral phenotype was caused by a presynaptic dopamine deficiency.
As noted above, Burroughs proposes the use of apomorphine as a disruptive agent to break "the circuit of positive feedback" of the orgasm death tune (Ticket 111).
Effects of central dopaminergic stimulation by apomorphine on swallowing disorders in Parkinson's disease," Movement Disorders, vol.
APL-130277 is a rapidly dissolving thin-film vehicle incorporating stabilizing ingredients with apomorphine in solid form, plus pH buffers to enhance stability, lower irritation and maintain optimal absorption.
Inhibitory effects of MK-801 on contextual sensitization to climbing behavior and on development of tolerance to hypothermia induced by a single high dose of apomorphine.
When combined with a dopaminergic agonist, apomorphine, beta-amyrin palmitate did not affect locomotor stimulation produced by apomorphine, suggesting that beta-amyrin palmitate might inhibit alpha1-adrenoceptors [128].
Hauser found that PD patients who failed to obtain good symptom control after taking a certain dopamine agonist drug, such as apomorphine (Apokyn), pramipexole (Mirapex), or ropinirole (Requip), achieved much greater symptom relief by taking the commonly prescribed PD drug rasagiline (Azilect).
In the rodent model, behavioral improvement was assessed using the cylinder test, amphetamine and apomorphine induced rotation tests.
Apomorphine is a drug used in specialist treatment for people severely disabled by refractory episodes of Parkinson's disease.
Suppression of tumor-cell growth and mitogen response by aporhine alkaloids, dicentrine, glaucine, coryadine and apomorphine.