apoptosis


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apoptosis

[‚ā·pō′tō·səs]
(cell and molecular biology)
Death of cells triggered by extracellular signals or genetically programmed events, carried out by processes within the cell, and characterized by systemic breakdown of cellular constituents, in particular chromosomal deoxyribonucleic acid; may be involved in normal development and aging, or may serve to eliminate defective or damaged cells. Also known as programmed cell death.
References in periodicals archive ?
applications of apoptosis and it is clear that significant drugs that
She expected that in the absence of this chemical partner, the cells would undergo apoptosis.
Idun's drug discovery programs focus on small molecule activators of apoptosis for applications in cancer as well as in small molecule inhibitors of apoptosis for applications in central nervous system disorders, cardiovascular disease and organ damage.
Current developments in cancer therapy base themselves on the deliberate and specific induction of apoptosis in cancer cells.
Guy Salvesen and Stuart Lipton, both from The Burnham Institute, will present data elucidating the mechanism of apoptosis and how these mechanisms play a role in disease.
One of the major mechanisms of sepsis-induced immunosuppression is due to apoptosis of the cells of the adaptive immune system (5).
Percentage Share Breakdown of Number of Apoptosis Modulating
The fragments were fixed, embedded in paraffin, and cut into serial 5-[micro]m-thick sections that were used for confirmation of the diagnosis, immunohistochemistry for the detection of TNF-[alpha], IFN-[gamma], Bcl-2, Fas, and iNOS, and detection of apoptosis by the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) technique.
Inhibition or depletion of the protein also caused preferential apoptosis in a variety of malignant cells in culture.