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(physical chemistry)
The ability of a substance to form a solution with another substance.



the ability of one substance to combine with another and form a homogeneous, thermodynamically stable system of variable composition made up of two or more components. These systems are formed upon interaction of gases with liquids, liquids with liquids, and other similar combinations. The ratios of the components to one another may be either arbitrary or restricted within certain limits. In the latter case, the solubility is said to be limited.

The solubility of a substance under given conditions is determined from the substance’s concentration in a saturated solution. The solubility of various substances in a specific solvent depends on external conditions, mainly on the temperature and pressure. The effect of pressure on solubility is most pronounced with gases. A change in external conditions affects solubility in accordance with the principle of equilibrium shift (see LECHÂTELiER’S PRINCIPLE). Solubility charts of various substances have been compiled for the most important solvents. Such charts either express solubility as a function of external conditions or simply list the solubility under standard conditions.

References in periodicals archive ?
This technology, which improves the bioavailability of compounds with low aqueous solubility, has been applied successfully to hundreds of compounds at various stages of development, from preclinical studies to Phase III clinical trials.
Hydroxypropyl betacyclodextrins are modified [beta]CDs having a higher aqueous solubility (above 60%) and a proven safe profile, especially for parenteral uses.
Distilled water was slowly circulated over the beads for a period of not less than 4 days; the beads were then used to make a Krebs-Ringer solution that contained PCB 153 at the limit of its aqueous solubility (reported as 0.
has yielded aqueous solubility data for over 20,000 compounds in the NIH Molecular Library within the first 90 days of screening and characterization.
There is a growing need for this technology, since it is estimated that more than 40% of drugs in development have low aqueous solubility.
nanolitre dispensing has become a prerequisite for any HTS lab, but the ability to rapidly and consistently measure aqueous solubility is critical to the successful identification of potential compounds.
Stuart continued, "We expect that the softgel platform's proven advantage in delivering compounds with limited aqueous solubility will be increasingly valuable to drug developers, and that the consistently proven patient/consumer preference for softgels will be increasingly important for clinical and marketing purposes.
The patent covers a spray-drying process for producing solid amorphous dispersions from drugs with low aqueous solubility and polymers.
As part of the S-ISCO(TM) process, VeruTEK uses its plant oil surfactants (VeruSOL(TM)) to increase the aqueous solubility of coal tars and then uses activated persulfate, a very strong free-radical oxidant system, to destroy the solubilized coal tars.