2007) In vitro and in vivo activities of T-705 against arenavirus
and bunyavirus infections.
The report provides a snapshot of the global therapeutic landscape of Arenavirus
Infection Lassa Fever
In 2008, a highly fatal outbreak of HF in Johannesburg was attributed to a previously unknown arenavirus
, dubbed the Lujo virus (i.
In addition to the recognized arenavirus
hosts, other Texas rodent genera (Onychomys, Baiomys, Peromyscus, Dipodomys, and Chaetodipus) have tested positive for arenavirus
antibodies (Milazzo et al.
LCMV is the only arenavirus
to exist in both areas; however, it is classified as an Old World virus.
Ramos B, Vasquez C, Tesh R (1997a) Isolation and characterization of Pirital Virus, a newly discovered South American Arenavirus
6%, which would fall very close to the proposed cut off between species and strains for other arenavirus
genotypes (Garcia et al.
Human infection with an arenavirus
is likely to be very uncommon.
typically is associated with wild wood rats and believed to be transmitted to humans in dust carrying an infected rodent's urine, feces or saliva, a health expert said Friday.
Intensive laboratory investigation attributed the outbreak to a novel arenavirus
, dubbed 'Lujo' (i.
Lymphocytic choriomeningitis virus (LCMV) is an arenavirus
carried by rodents, most notably domestic house mice (Mus musculus), but also laboratory and pet rodents (1).
They discuss such aspects as viral bioterrorism and antiviral countermeasures, antiviral drug targets and strategies, perspectives on the therapy against Arenavirus
infections, Ebola, exploiting the error-prone replication of riboviruses for antiviral therapy, the structural biology of flaviviral replication and opportunities for drug design, West Nile virus, the emergence of pandemic influenza A, smallpox, and the role of the Vaccina virus E3L and K3L genes in viral countermeasures to the host interferon response.