However, the patient was treated with a routine chemotherapy of high dose cytosine arabinoside, idarubicin, arsenic trioxide
, and all-trans retinoic acid with subsequent bone marrow observations
The protein extracts from normal rat liver cells and HepG2 cell line exposed to arsenic trioxide
only were used for western blotting because results of survival assays indicated that cadmium chloride induced toxicity was possibly not p53 mediated.
is generated from processing arsenic compounds, and while a high level of arsenic is known to be carcinogenic, low doses can be therapeutic in selected patients, said Uren.
, a treatment option for acute promyelocytic leukemia (APL) (Zhou et al.
Food and Drug Administration has already approved arsenic trioxide
for use in humans, which could pave the way for clinical trials of this approach.
The voluntary decision by the wood preservative industry to eliminate CCA for certain wood products has led to a major decline in arsenic trioxide
consumption and a decline in production mainly in China.
KEY WORDS: Akt signaling, arsenic trioxide
, myogenic differentiation.
11 Application of Arsenic Trioxide
Therapy for Patients with Leukaemia (Bo Yuan, Yuta Yoshino, Toshikazu Kaise and Hiroo Toyoda).
Whether from medical therapy (as with the use of arsenic trioxide
in advanced malignancies) or malicious intent (as in acute poisoning), the cardiac effects of massive acute arsenic exposure are well documented (Hall and Harruff 1989; Little et al.
Drug approval summaries: arsenic trioxide
, tamoxifen citrate, anastrazole, paclitaxel, bexarotene.
By comparison, >10oM of arsenic trioxide
or inorganic arsenic (ATO) for 48 hours was required to induce 40% apoptosis in TCL and 25% apoptosis in L428 cells.
We have previously shown that aquaglyceroporin channels, including Escherichia coli GlpF, Saccharorayces cerevisiae Fps1p, AQP7, and AQP9 from rat and human, conduct trivalent inorganic arsenic [As(III)] as arsenic trioxide
, the protonated form of arsenite.