atheroma

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atheroma

[‚ath·ə′rōm·ə]
(medicine)
A lipid deposit in the inner wall of an artery; characteristic of atherosclerosis.
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References in periodicals archive ?
12) They may also cause a generalized immune response promoting a worsening of chronically inflamed arterial plaques.
Among all the participants who were obese, those who carried the APOA5 gene variant showed a significantly greater buildup of arterial plaque than those who did not carry the gene.
The association between the gene variant and hardening of the arteries requires further study; so far, however, the comparatively high levels of arterial plaque among carriers is consistent with levels associated with symptoms of heart disease.
Using intravascular ultrasound (IVUS), researchers measured arterial plaques before and after the six-week study.
Major Finding: Among 154 patients with rheumatoid arthritis, those taking TNF inhibitors had " significantly less arterial plaque 5* load progression than did those not taking the drug.
ENHANCE showed that Vytorin was not better than simvastatin alone at reducing arterial plaque build-up.
Researchers tracked cholesterol esters bound to saturated fat, which have been linked to dangerous arterial plaque buildup and occur at higher levels in coronary artery disease patients.
Other tests that were rated class III included advanced lipid testing with measurement of apolipoproteins and particle size and density, MRI for the detection of arterial plaque, measurement of natriuretic peptide levels, and coronary CT angiography.
For instance, there's some preliminary evidence that isoflavones can use other means to suppress the activity of growth factors--a group of regulatory proteins--including at least one that fosters the buildup of arterial plaque.
Reacting to the release of the ENHANCE trial results that showed Vytorin, a combination of the statin simvastatin (Zocor) and ezetimibe (Zetia), provides no benefit over simvastatin alone in preventing the progress of arterial plaque buildup, physicians indicate they will shift Vytorin heavily to third-line, rather than first- or second- line use, in treating patients at risk for coronary heart disease, according to new research by GfK Market Measures.
CoroStim - The first vibrational-energy-emitting pacemaker add-on designed to prevent arterial plaque formation in high-risk patients.
Thus, endothelial dysfunction is one of the first steps in the creation of atherosclerosis--the buildup of arterial plaque that elevates the risk for heart attack, stroke, and congestive heart failure.