artificial kidney


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kidney, artificial,

mechanical device capable of assuming the functions ordinarily performed by the kidneys. In treating cases of kidney failure a tube is inserted into an artery in the patient's arm and blood is channeled through semipermeable tubes immersed in a bath containing all the normal blood chemicals except urea and other metabolic waste products. Since the concentration of harmful metabolic wastes are higher in the blood than in the bath, they pass through the walls of the tubes into the bath and purified blood is returned to the body. This process of blood purification, called hemodialysis (see dialysisdialysis
, in chemistry, transfer of solute (dissolved solids) across a semipermeable membrane. Strictly speaking, dialysis refers only to the transfer of the solute; transfer of the solvent is called osmosis.
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), is continuous or intermittent, depending on the residual kidney function in the patient. Kidney transplants usually make hemodialysis unnecessary.

artificial kidney:

see kidney, artificialkidney, artificial,
mechanical device capable of assuming the functions ordinarily performed by the kidneys. In treating cases of kidney failure a tube is inserted into an artery in the patient's arm and blood is channeled through semipermeable tubes immersed in a bath
..... Click the link for more information.
.

Kidney, Artificial

 

hemodialyzer, an apparatus for the temporary replacement of the excretory function of the kidneys.

The artificial kidney is used to rid the blood of metabolic products, to correct electrolyte-water and acid-alkaline balances in acute and chronic renal insufficiency, to remove dialyzing toxic substances in cases of poisoning, and to remove excess water in cases of edema. In 1913 the American scientist J. Abel created an apparatus for dialysis that was the basis for the design of the artificial kidney; in 1944 the Dutch scientist W.J. Kolff was the first to employ an artificial kidney successfully.

The artificial kidney operates on the principle of the dialysis of substances through a semipermeable membrane (cellophane). Dialysis is a result of the differences in the concentrations of substances in the blood and in the dialyzing solution, which contains glucose and the principal electrolytes of the blood in nearly physiological concentrations without containing any of the substances that must be removed from the body (urea, creatinine, uric acid, sulfates, phosphates). Proteins, formed elements of the blood, bacteria, and substances with a molecular weight of more than 30,000 do not pass through the membrane. During hemodialysis (that is, the operation of the artificial kidney; see Figure 1) the patient’s blood is drawn off through a catheter by a pump from the inferior vena cava and passed inside the chambers of cellophane sheets of the dialyzer; these chambers are washed outside by the dialyzing solution, which is supplied by another pump. Partially purified, the blood is returned to one of the surface veins.

Figure 1. Diagram of Soviet-model artificial kidney apparatus: (1) catheter, (2) pump, (3) dialyzer, (4) catheter for returning blood to the patient, (5) tank for the dialyzing solution

Hemodialysis takes between four and 12 hours; during that time anticoagulants (heparin) are administered to keep the blood from clotting. In acute renal insufficiency the hemodialysis is repeated every three to six days until renal function is restored. With chronic insufficiency, when the treatment is necessary two or three times a week for several months or years, the artificial kidney is hooked up to a teflon shunt that is implanted between the radial artery and the surface vein of the forearm; in this case the blood can enter the dialyzer without the use of a pump. In the USSR, Sweden, France, and the United States, artificial kidney treatment is conducted in special centers that deal with kidney disturbances. The models used in the USSR are developed by the Scientific Research Institute of Experimental Surgical Equipment and Instruments of the Ministry of Public Health of the USSR. Semiautomatic systems for preparing the dialyzing solution and delivering it to the dialyzer are used in performing hemodialysis on several patients simultaneously.

REFERENCES

Iskusstvennaia pochka i ee klinicheskoe primenenie. Moscow, 1961.
Fritz, K.W. Hamodialyse. Stuttgart, 1966.

A. A. TRIKASHNYI

artificial kidney

[¦ärd·ə¦fish·əl ′kid·nē]
(medicine)
An apparatus that performs the work of the kidney in purifying blood; used only in cases of renal failure or shutdown.
References in periodicals archive ?
The artificial kidney being developed by Roy and Fissell is designed to be connected internally to the patient's blood supply and bladder and implanted near the patient's own kidneys, which are not removed.
Toray and TMC are planning to build a plant for manufacturing artificial kidneys at a site adjacent to the dialysis machine plant by investing about 6 billion yen, aiming to start sales in the latter half of 2014.
Our vision of a technological breakthrough has materialised in the form of a wearable artificial kidney, which provides continuous dialysis 24 hours a day, seven days a week," said Victor Gura of the David Geffen School of Medicine, University of California.
During mid seventies while one of us (CPS) was in Utah, Wearable Artificial Kidney was also being developed on experimental stage; CPS still remembers the morning meetings and lively discussion sessions with visitors and his faculty.
said Thursday it will triple its global production of artificial kidney devices used for dialysis treatment equipment by 2010 to meet growing global demand.
Working on his own he invented and used the world's first successful artificial kidney.
In 1943, at Kampen Hospital, Kolff built the first artificial kidney from wooden slats, a sausage casing, a gear pump and a porcelain bathtub.
One needle removes the blood and routes it to the artificial kidney machine and the second returns the blood to the patient.
The artificial kidney has two parts, one for your blood and one for a washing fluid called dialysate.
The platform leads to three initial products: a Portable Artificial Kidney (PAK) for attended care Renal Replacement Therapy (RRT) for patients suffering from Acute Renal Failure, a PAK for home hemodialysis (XCR-6) for patients suffering from End Stage Renal Disease (ESRD), and a Wearable Artificial Kidney (WAK) for continuous ambulatory hemodialysis for treatment of ESRD.
The ultimate goal was to improve the artificial kidney for the end user--the patient.

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