artificial kidney

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artificial kidney:

see kidney, artificialkidney, artificial,
mechanical device capable of assuming the functions ordinarily performed by the kidneys. In treating cases of kidney failure a tube is inserted into an artery in the patient's arm and blood is channeled through semipermeable tubes immersed in a bath
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kidney, artificial,

mechanical device capable of assuming the functions ordinarily performed by the kidneys. In treating cases of kidney failure a tube is inserted into an artery in the patient's arm and blood is channeled through semipermeable tubes immersed in a bath containing all the normal blood chemicals except urea and other metabolic waste products. Since the concentration of harmful metabolic wastes are higher in the blood than in the bath, they pass through the walls of the tubes into the bath and purified blood is returned to the body. This process of blood purification, called hemodialysis (see dialysisdialysis
, in chemistry, transfer of solute (dissolved solids) across a semipermeable membrane. Strictly speaking, dialysis refers only to the transfer of the solute; transfer of the solvent is called osmosis.
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), is continuous or intermittent, depending on the residual kidney function in the patient. Kidney transplants usually make hemodialysis unnecessary.

Kidney, Artificial


hemodialyzer, an apparatus for the temporary replacement of the excretory function of the kidneys.

The artificial kidney is used to rid the blood of metabolic products, to correct electrolyte-water and acid-alkaline balances in acute and chronic renal insufficiency, to remove dialyzing toxic substances in cases of poisoning, and to remove excess water in cases of edema. In 1913 the American scientist J. Abel created an apparatus for dialysis that was the basis for the design of the artificial kidney; in 1944 the Dutch scientist W.J. Kolff was the first to employ an artificial kidney successfully.

The artificial kidney operates on the principle of the dialysis of substances through a semipermeable membrane (cellophane). Dialysis is a result of the differences in the concentrations of substances in the blood and in the dialyzing solution, which contains glucose and the principal electrolytes of the blood in nearly physiological concentrations without containing any of the substances that must be removed from the body (urea, creatinine, uric acid, sulfates, phosphates). Proteins, formed elements of the blood, bacteria, and substances with a molecular weight of more than 30,000 do not pass through the membrane. During hemodialysis (that is, the operation of the artificial kidney; see Figure 1) the patient’s blood is drawn off through a catheter by a pump from the inferior vena cava and passed inside the chambers of cellophane sheets of the dialyzer; these chambers are washed outside by the dialyzing solution, which is supplied by another pump. Partially purified, the blood is returned to one of the surface veins.

Figure 1. Diagram of Soviet-model artificial kidney apparatus: (1) catheter, (2) pump, (3) dialyzer, (4) catheter for returning blood to the patient, (5) tank for the dialyzing solution

Hemodialysis takes between four and 12 hours; during that time anticoagulants (heparin) are administered to keep the blood from clotting. In acute renal insufficiency the hemodialysis is repeated every three to six days until renal function is restored. With chronic insufficiency, when the treatment is necessary two or three times a week for several months or years, the artificial kidney is hooked up to a teflon shunt that is implanted between the radial artery and the surface vein of the forearm; in this case the blood can enter the dialyzer without the use of a pump. In the USSR, Sweden, France, and the United States, artificial kidney treatment is conducted in special centers that deal with kidney disturbances. The models used in the USSR are developed by the Scientific Research Institute of Experimental Surgical Equipment and Instruments of the Ministry of Public Health of the USSR. Semiautomatic systems for preparing the dialyzing solution and delivering it to the dialyzer are used in performing hemodialysis on several patients simultaneously.


Iskusstvennaia pochka i ee klinicheskoe primenenie. Moscow, 1961.
Fritz, K.W. Hamodialyse. Stuttgart, 1966.


artificial kidney

[¦ärd·ə¦fish·əl ′kid·nē]
An apparatus that performs the work of the kidney in purifying blood; used only in cases of renal failure or shutdown.
References in periodicals archive ?
Shuvo Roy, an associate professor of bioengineering and therapeutic sciences at the University of California, has developed an early-stage implantable artificial kidney.
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Table 21: World Recent Past, Current & Future Analysis for Artificial Organs by Product Segment -Artificial Heart, Artificial Kidneys, Artificial Liver, Artificial Pancreas and Artificial Lungs Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2010 (includes corresponding Graph/Chart) II-88
Table 3: Leading Players in the Worldwide HemodialysisEquipment and Supplies Market (2011) - Percentage Breakdownof Sales for Fresenius Medical Care, Gambro, Baxter andOthers (includes corresponding Graph/Chart) II-11Competitive Landscape of Artificial Kidney or Dialyzers Market II-11
The winning students, ranging from grades K-12, will use prototype models and websites to explain their projects, including: An "Animal Detector Belt" that uses sensors and computer technology to warn hikers of the presence of dangerous animals (Virginia Beach, VA) Genetically enhanced living plants that extract pollutants from soil as they grow (Burke, VA) "Kidneys of Tomorrow", rejection-proof artificial kidneys grown from a patient's own cells (Merion Station, PA) A prosthetic limb that offers greater mobility and a wider range of feeling than ones that exist today (Toronto, Canada) A lifesaving pill that starves cancerous tumors (Dublin, CA) A "Bath Butler" that automatically recognizes you and fills your bath with hot, recycled water at the temperature and level you prefer.
Disposable artificial kidneys have been reprocessed and reused in chronic hemodialysis for more than twenty years.
AEMD-45, like all product offerings from Aethlon Medical, is developed from an expansive platform technology known as the Hemopurifier(TM), which employs a proprietary method to increase the capability of FDA cleared artificial kidneys (hemodialysis cartridges) to bind infectious viruses and toxic proteins from human blood before cells are infected.
The ultimate goal of Professor Little s research is to produce artificial kidneys for humans.

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