Building upon this success, I will develop methodology to enable, under mild aqueous conditions, a greater diversity of cross-coupling reactions of aryl halide
containing small molecules and then NPs to be employed.
The Sonogashira cross-coupling reaction takes place between aryl halide (ArX) and terminal acetylene, catalysed by a zerovalent palladium catalyst to produce diyne (see Fig.
Oxidative addition (reaction of aryl halide with a zerovalent palladium catalyst) is often described as a rate-limiting step, and numerous papers are dedicated to the experimental and theoretical investigations of its kinetics and mechanism [12-15].
At its core, a Buchwald-Hartwig amination is an aryl halide
reacting with an amine [see above example].
It is thought that increasing electronic donation into the palladium metal center from the phosphine will aide in oxidative addition into the aryl halide bond.
PALLADIUM CATALYZED SUZUKI COUPLING WITH WATER-SOLUBLE PHOSPHINE LIGANDS TO PROMOTE ACTIVATION OF ARYL HALIDES.
Jiang, Efficient Iron-Catalyzed N-Arylation of Aryl Halides
with Amines, Org.
Among the topics are the copper-catalyzed formation of carbon-phosphorous bonds with aryl halides
, insights into the mechanism of modern Ullmann-Goldberg coupling reactions, copper-catalyzed alkynylation and alkenylation reactions of alkynyl derivatives, applying copper-mediated carbon-nitrogen bond formation in complex molecule synthesis, and reusable catalysts for copper-mediated cross-coupling reactions under heterogeneous conditions.
In addition, aromatic boronic esters can be conveniently prepared through palladium-catalyzed borylation of aryl halides
with the diboron reagent (Scheme 3).
Copper iodide nanostructure has numerous applications, including its application as a catalyst in the synthesis of phenol, aniline, and thiophenols from aryl halides
in aqueous solutions.
Robichaud, 2005),or prepared via an SNAr reaction of piperazine with aryl halides
containing electron-withdrawing groups to the mono N-aryl piperazine which are then reacted with appropriate arylhalides (T.
However, the reactions did not work well with primary alkyl or aryl halides