poliomyelitis (redirected from ascending poliomyelitis)

poliomyelitis (pō'lēōmī'əlī`tĭs), polio, or infantile paralysis, acute viral infection, mainly of children but also affecting older persons. There are three immunologic types of poliomyelitis virus; exposure to one type produces immunity only to that type, so infection with the other types is still possible. Spread of the infection is primarily through contact with an infected person. Most people who contract polio either exhibit no symptoms or experience only minor illness; however, such individuals can harbor the virus and spread it to others. Less than 1% of the people who get infected develop paralysis.

The virus enters the body by way of the mouth, invades the bloodstream, and may be carried to the central nervous system, where it causes lesions of the gray matter of the spinal cord and brain. The illness begins with fever, headache, stiff neck and back, and muscle pain and tenderness. If there is involvement of the central nervous system, paralysis ensues. Of those patients who develop paralytic poliomyelitis, about 25% sustain severe permanent disability, another 25% have mild disabilities, and 50% recover with no residual paralysis. The disease is usually fatal if the nerve cells in the brain are attacked (bulbar poliomyelitis), causing paralysis of essential muscles, such as those controlling swallowing, heartbeat, and respiration. There is no specific drug for treatment. For reasons not clearly understood, some people who have had severe polio experience postpolio syndrome, a condition in which new weakness and pain occurs years later in previously affected muscles.

The incidence of poliomyelitis declined radically in the United States when a mass immunization program with the Salk vaccine, a preparation made from killed organisms and injected, was begun in 1955. By 1961 the Sabin vaccine, a preparation made from weakened living organisms and taken orally, was released for use. Since then the disease has been virtually eliminated in the Americas, Europe, and Australasia, but vaccination programs continue because of polio's existence in other parts of the world (mainly South Asia and parts of East and West Africa) and the ease of travel.

In 1988 the World Health Organization began a global vaccination campaign to eradicate the disease—which continued to paralyze hundreds of thousands of children each year—by 2000. Although the date of eradication was later pushed back to 2005 (and even later a set deadline was abandoned), by 2003 there were less than a thousand new cases of polio worldwide. In 2003–4 the campaign was slowed when Muslim states in N Nigeria refused to use vaccines they believed would sterilize women, leading to an increase in cases there and in neighboring countries and to outbreaks of the disease in 17 countries including Yemen and Indonesia. Some other African countries also experienced new outbreaks of the disease from other sources. However, by early 2007, polio was, according to WHO, endemic in India, Pakistan, Afghanistan, and Nigeria. Other experts also classified cases in Somalia and Ethiopia as endemic, and the status of the disease in Congo (Kinshasa), where civil war had long disrupted medical care, was unclear.

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poliomyelitis

 or polio or infantile paralysis

Acute infectious viral disease that can cause flaccid paralysis of muscles. Severe epidemics killed or paralyzed many people, mostly children and young adults, until the 1960s, when Jonas Salk's injectable killed vaccine and Albert B. Sabin's oral attenuated live vaccine controlled polio in the developed world. Flulike symptoms with diarrhea may progress to back and limb pain, muscle tenderness, and stiff neck. Destruction of spinal cord motor cells causes paralysis, ranging from transient weakness to complete, permanent paralysis, in fewer than 20% of patients. Patients may lose the ability to use their limbs, to breathe, or to swallow and speak. They may need physical medicine and rehabilitation, mechanical breathing assistance, or tracheal suction to remove secretions. A “postpolio syndrome” occurs decades later in some cases, with weakness of muscles that had recovered.

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poliomyelitis

an acute infectious viral disease, esp affecting children. In its paralytic form (acute anterior poliomyelitis) the brain and spinal cord are involved, causing weakness, paralysis, and wasting of muscle

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poliomyelitis [¦pō·lē·ō‚mī·ə′līd·əs]

(medicine)

An acute infectious viral disease which in its most serious form involves the central nervous system and, by destruction of motor neurons in the spinal cord, produces flaccid paralysis. Also known as Heine-Medin disease; infantile paralysis.

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Poliomyelitis

An acute infectious viral disease which in its serious form affects the central nervous system and, by destruction of motor neurons in the spinal cord, produces flaccid paralysis. However, about 99% of infections are either inapparent or very mild. See Animal virus, Central nervous system

The virus probably enters the body through the mouth; primary multiplication occurs in the throat and intestine. Transitory viremia occurs; the blood seems to be the most likely route to the central nervous system. The severity of the infection may range from a completely inapparent through minor influenzalike illness, or an aseptic meningitis syndrome (nonparalytic poliomyelitis) with stiff and painful back and neck, to the severe forms of paralytic and bulbar poliomyelitis. In all clinical types, virus is regularly present in the enteric tract. In paralytic poliomyelitis the usual course begins as a minor illness but progresses, sometimes with an intervening recession of symptoms (hence biphasic), to flaccid paralysis of varying degree and persistence. When the motor neurons affected are those of the diaphragm or of the intercostal muscles, respiratory paralysis occurs. Bulbar poliomyelitis results from viral attack on the medulla (bulb of the brain) or higher brain centers, with respiratory, vasomotor, facial, palatal, or pharyngeal disturbances.

Poliomyelitis occurs throughout the world. In temperate zones it appears chiefly in summer and fall, although winter outbreaks have been known. It occurs in all age groups, but less frequently in adults because of their acquired immunity. The virus is spread by human contact; the nature of the contact is not clear, but it appears to be associated with familial contact and with interfamily contact among young children. The virus may be present in flies.

Inactivated poliovirus vaccine (Salk; IPV), prepared from virus grown in monkey kidney cultures, was developed and first used in the United States, but oral poliovirus vaccine (Sabin; OPV) is now generally used throughout the world. The oral vaccine is a living, attenuated virus.