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The ALTS study concluded that ASCUS and LSIL patients who have a positive HPV16 diagnosis by genotyping are at significantly greater risk for detection of high-grade abnormalities during a 2-year follow-up period when compared to those who test positive for another oncogenic type of HPV or who are HPV-negative," commented Cosette Wheeler, Ph.
More than 85% of findings of ASCUS from Pap tests in the United States are now being followed by reflex HPV testing, and more than 25% to 30% of women 30 years and older are being routinely screened with cytology and HPV cotesting.
The study also found that among 146 ASCUS samples in women followed at least 2 years since the test, 123 (84%) had disease regression before the following visit.
To establish clinical, cytopathologic, and microbiologic guidelines for the evaluation and management of a diagnosis of ASCUS/LSIL, we evaluated the rate of high-risk HPV infection in patients with diagnoses of within normal limits (WNL), benign cellular changes (BCC), ASCUS, LSIL, and HSIL, and compared the relationships between histologic features and the presence of high-risk HPV DNA in each cytologic group.
Many different forms of ASCUS can be defined, some of which have much more clinical significance than do others.
The 1991 system's three-tiered designation for ASCUS results--either "favor reactive," or "favor a squamous intraepithelial lesion," or "not otherwise specified (NOS)--has been found to be subjective and not very consistent, Dr.
Numerous clinical studies have demonstrated the effectiveness of HPV testing as a follow-up to ASCUS Pap results and a recent study by the National Cancer Institute highlighted the benefits of HPV testing using Digene's hc2 HPV Test directly from Cytyc's ThinPrep(R) Pap Test(TM) vial in managing women with ASCUS Pap results.
In addition to major national labs, including Quest Diagnostics, Unilab Corporation and American Medical Laboratories, most regional and many local labs around the country now offer the HC2 HPV Test to physicians for the triage of women with borderline Pap results known as ASCUS (atypical squamous cells of undetermined significance).
ASCUS results are a source of frustration for clinicians because of the uncertainty about what they should do next for their patients, which sometimes results in further treatment that is costly and, possibly, unnecessary.
Women 18-60 years old were followed over the course of the 5-year study to determine the main predictors of cytologic progression to squamous intraepithelial lesions (SIL) from ASCUS.
Digene Corporation announced today that new results from the largest cervical cancer screening management trial in the United States to date confirm that HPV testing, using Digene's Hybrid Capture(R) 2 HPV DNA Test, is a more effective way to manage women in high-risk age groups who have abnormal Pap test results known as ASCUS (atypical squamous cells of undetermined significance).
Digene Corporation and Cytyc Corporation today announced that the American Medical Women's Association (AMWA) has developed new patient guidelines that recommend testing for human papillomavirus (HPV) for the millions of women each year who receive abnormal results known as ASCUS following their routine Pap test.
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